摘要
目的:观察亚低温联合静脉溶栓治疗急性脑梗死(ACI)患者的效果。方法:选取2020年5月至2021年5月该院收治的86例ACI患者进行前瞻性研究,按照随机数字表法将其分为对照组和观察组各43例。两组均进行常规治疗,在此基础上,对照组行静脉溶栓治疗,观察组在对照组基础上联合亚低温治疗,两组均治疗2周。比较两组临床疗效,治疗前后神经功能缺损[美国国立卫生研究院卒中量表(NIHSS)]评分、脑源性神经营养因子(BDNF)水平、氧化应激指标[丙二醛(MDA)、超氧化物歧化酶(SOD)]水平,以及并发症发生率。结果:观察组治疗总有效率为95.35%(41/43),高于对照组的81.40%(35/43),差异有统计学意义(P<0.05);治疗后,观察组NIHSS评分、MDA水平均低于对照组,BDNF、SOD水平均高于对照组,差异有统计学意义(P<0.05);两组并发症发生率比较,差异无统计学意义(P>0.05)。结论:亚低温联合静脉溶栓治疗ACI患者可提高治疗总有效率和BDNF水平,改善氧化应激指标水平,降低NIHSS评分,效果优于单纯静脉溶栓治疗。
Objective:To observe effects of mild hypothermia combined with intravenous thrombolysis in treatment of patients with acute cerebral infarction(ACI).Methods:A prospective study was conducted on 86 ACI patients admitted to the hospital from May 2020 to May 2021.They were divided into control group and observation group according to the random number table method,43 cases in each group.Both groups received routine treatment.On this basis,the control group was treated with intravenous thrombolysis,while the observation group was treated with mild hypothermia on the basis of that of the control group.Both groups were treated for 2 weeks.The clinical efficacy,the neurological deficit score[National Institutes of Health Stroke scale(NIHSS)],the brain-derived neurotrophic factor(BDNF)level,the oxidative stress index levels[malondialdehyde(MDA),superoxide dismutase(SOD)]before and after the treatment,and the incidence of complications were compared between the two groups.Results:The total effective rate of treatment in the observation group was 95.35%(41/43),which was higher than 81.40%(35/43)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the NIHSS score and the MDA level of the observation group were lower than those of the control group,the levels of BDNF and SOD were higher than those of the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of complications between the two groups(P>0.05).Conclusions:Mild hypothermia combined with intravenous thrombolysis in the treatment of the ACI patients can improve the total effective rate of treatment and the BDNF levels,improve the level of oxidative stress indexes,and reduce the NIHSS scores.Moreover,it is superior to single intravenous thrombolysis.
作者
褚春沐
CHU Chunmu(Second Department of Neurology of the Central Hospital of Jiamusi City,Jiamusi 154000 Heilongjiang,China)
出处
《中国民康医学》
2023年第12期17-20,共4页
Medical Journal of Chinese People’s Health
关键词
急性脑梗死
静脉溶栓
阿替普酶
亚低温
神经功能缺损
氧化应激
脑源性神经营养因子
Acute cerebral infarction
Intravenous thrombolysis
Alteplase
Mild hypothermia
Neurological deficit
Oxidative stress
Brain-derived neurotrophic factor
