摘要
目的:观察鳖甲煎丸联合常规西药治疗老年肝硬化患者的效果。方法:选取2020年5月至2022年5月该院收治的80例老年肝硬化患者进行前瞻性研究,按随机数字表法将其分为对照组(n=40)和观察组(n=40)。对照组给予常规西药治疗,观察组在对照组基础上联合鳖甲煎丸治疗,比较两组临床疗效、治疗前后肝功能指标[天门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)及总胆红素(TBIL)]水平、肝纤维化指标[透明质酸(HA)、Ⅲ型前胶原(PCⅢ)及层粘连蛋白(LN)]水平、肝脏硬度和慢性乙型肝炎脱氧核糖核酸(HBV DNA)水平。结果:观察组治疗总有效率为90.00%(36/40),高于对照组的72.50%(29/40),差异有统计学意义(P<0.05);治疗后,两组AST、ALT、TBIL、HA、PCⅢ和LN水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组肝脏硬度、HBV DNA水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。结论:鳖甲煎丸联合常规西药治疗老年肝硬化患者可提高治疗总有效率,降低肝功能指标水平、肝纤维化指标水平、肝脏硬度和HBV DNA水平,效果优于单纯常规西药治疗。
Objective:To observe effects of Biejiajian pills combined with conventional western medicine in treatment of elderly patients with liver cirrhosis.Methods:A prospective study was conducted on 80 elderly patients with liver cirrhosis admitted to the hospital from May 2020 to May 2022.They were divided into observation group and control group(n=40)and observation group(n=40)according to the random number table method.The control group was treated with conventional western medicine,while the observation group was treated with Biejiajian pills on the basis of that of the control group.The clinical efficacy,the liver function index levels[aspartate aminotransferase(AST),alanine aminotransferase(ALT)and total bilirubin(TBIL)],the liver fibrosis index levels[hyaluronic acid(HA),type III procollagen(PCIII)and laminin(LN)],the liver stiffness,and the chronic hepatitis B deoxyribonucleic acid(HBV DNA)levels were compared between the two groups before and after the treatment.Results:The total effective rate of treatment in the observation group was 90.00%(36/40),which was higher than 72.50%(29/40)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of AST,ALT,TBIL,HA,PCIII and LN in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Further,after the treatment,the levels of liver stiffness and HBV DNA in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusions:Biejiajian pills combined with conventional western medicine in the treatment of the elderly patients with liver cirrhosis can improve the total effective rate of treatment and reduce the levels of liver function indexes,liver fibrosis indexes,liver stiffness and HBV DNA levels.Moreover,it is superior to single conventional western medicine treatment.
作者
崔嘉
车启富
孔媛
CUI Jia;CHE Qifu;KONG Yuan(Jiamusi Hospital of Traditional Chinese Medicine,Department of Pharmacy,Jiamusi 154002 Heilongjiang,China;Jiamusi Hospital of Traditional Chinese Medicine,Department of Cardiac Pulmonary Disease,Jiamusi 154002 Heilongjiang,China)
出处
《中国民康医学》
2023年第12期92-94,98,共4页
Medical Journal of Chinese People’s Health
关键词
慢性乙型肝炎
老年肝硬化
鳖甲煎丸
肝功能
肝纤维化
肝脏硬度
Chronic hepatitis B
Elderly cirrhosis
Biejiajian pills
Liver function
Liver fibrosis
Liver stiffness
