摘要
目的研讨前列地尔联合厄贝沙坦治疗糖尿病肾病蛋白尿的临床效果。方法随机抽取2018年1月—2022年1月三明市沙县区总医院内科三区治疗的72例糖尿病肾病蛋白尿患者为研究对象,按照随机抽签法分为对照组和观察组,每组36例。给予对照组患者单一前列地尔治疗,观察组患者选择前列地尔联合厄贝沙坦治疗。对比两组患者的24 h尿蛋白定量、治疗效果、肾功能指标、恢复指标、炎症水平及不良反应发生情况。结果治疗后,观察组24 h尿蛋白定量和24h尿微白蛋白排泄量均低于对照组,差异有统计学意义(P<0.05)。观察组的治疗有效率明显高于对照组,差异有统计学意义(P<0.05)。治疗后,观察组的血肌酐、血钾以及尿素氮水平均低于对照组,差异有统计学意义(P<0.05)。观察组餐后2 h血糖和空腹血糖水平均低于对照组,症状体征缓解时间和2 h尿蛋白定量下降50%时间均短于对照组,差异有统计学意义(P<0.05)。观察组TNF-α及IL-18水平均低于对照组,差异有统计学意义(P<0.05)。观察组的不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论给予糖尿病肾病蛋白尿患者前列地尔联合厄贝沙坦治疗,效果显著,并发症发生率较低,可切实改善患者的肾功能及血糖水平。
Objective To study the clinical effect of alprostadil combined with irbesartan in the treatment of protein-uria in diabetic nephropathy.Methods A total of 72 patients with diabetic nephropathy proteinuria treated in the third district of the Department of Internal Medicine of Shaxian District General Hospital of Sanming City from January 2018 to January 2022 were randomly selected as the study subjects,and were divided into control group and observa-tion group according to the random drawing method,with 36 cases in each group.A single alprostadil was given to the control group,and the observation group was treated with alprostadil combined with irbesartan.The 24-hour urine pro-tein quantification,treatment effect,renal function index,recovery index,inflammation level and occurrence of ad-verse reactions were compared between the two groups.Results After treatment,the 24-hour urine protein quantifica-tion and 24-hour urine microalbumin excretion in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The effective rate of treatment of the observation group was significantly higher than that of the control group,and the difference was statistically significant(P<0.05).After treat-ment,the serum creatinine,serum potassium and urea nitrogen levels in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The observation group had lower levels of 2 h after prandial glucose and fasting blood glucose levels than those in the control group,and the time for the relief of symptoms and signs and the quantitative decrease of urine protein in 2 h by 50%were shorter than those in the con-trol group,and the difference was statistically significant(P<0.05).The levels of TNF-αand IL-18 in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).The inci-dence of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Alprostadil combined with irbesartan in patients with diabetic nephropa-thy proteinuria has significant effect,low complication rate,and can effectively improve renal function and blood glu-cose level of patients.
作者
蒋珍莲
李小伟
罗爱清
JIANG Zhenlian;LI Xiaowei;LUO Aiqing(Department of Internal Medicine III,Shaxian District General Hospital,Sanming,Fujian Province,365050 China)
出处
《糖尿病新世界》
2023年第9期178-182,共5页
Diabetes New World Magazine
关键词
糖尿病肾病蛋白尿
前列地尔
厄贝沙坦
治疗效果
Diabetic nephropathy proteinuria
Alprostadil
Irbesartan
Treatment effect
