摘要
【目的】通过对《傅青主女科》《妇人大全良方》《济阴纲目》《经效产宝》《竹林寺女科》这5本妇科经典专著中治疗先兆流产的方剂的整理、分析,挖掘其中的用药规律,以期为现代中医临床治疗先兆流产提供用药参考。【方法】筛选该5本中医妇科经典专著中治疗先兆流产的方剂,建立数据库,统计方剂药物的用药频次、功效归类、性味、归经等,运用关联规则分析及聚类分析挖掘其药物组合及新方组合。【结果】共筛选得到治疗先兆流产的方剂110首,涉及中药98味。出现频次≥10次的高频中药有当归、川芎、阿胶、甘草、人参、生地黄、白芍、白术、艾叶、葱白、黄芩、熟地黄、茯苓、桑寄生、续断,共15味。高频中药的功效以补虚为主,性味多甘温,多归肝、脾、肾经。高频中药的关联规则分析共得到药物组合15个,频次最高的为当归-川芎;聚类分析得到新方组合3个。【结论】中医妇科经典专著中治疗先兆流产的用药以补虚为主,性味多甘温,多归肝、脾、肾经,治法以补虚固冲、益气养血、活血化瘀为主,安胎用药具有一定的特色,可为现代中医临床治疗先兆流产提供参考。
Objective The prescriptions for the treatment of threatened abortion in the five classical gynecological monographs,namely FU Qing-Zhu’s Gynecology and Obstetrics(FU Qing Zhu NüKe),A Complete Collection of Effective Prescriptions Women(Fu Ren Da Quan Liang Fang),A Compendium of Treatise for Female Diseases(Ji Yin Gang Mu),Valuable Experience in Obstetrics(Jing Xiao Chan Bao)and Zhulin Temple’s Book on Gynecology(Zhu Lin Si NüKe)were sorted out and analyzed,and then the medication rules for threatened abortion were explored,so as to provide a reference for the use of Chinese medicine in the treatment of threatened abortion in modern traditional Chinese medicine(TCM)clinics.Methods A database of prescriptions for the treatment of threatened abortion in the five classical monographs of traditional Chinese gynecology was established firstly.And then the medication frequency,efficacy classification,nature,flavors and meridian tropism of the herbs in the formulas were counted.Finally,the herbal combinations and new prescription combinations were explored by using association rule analysis and cluster analysis respectively.Results A total of 110 formulas for the treatment of threatened abortion were screened out,involving 98 herbs.There were 15 high-frequency herbs appearing more than 10 times,and they were Angelicae Sinensis Radix,Chuanxiong Rhizoma,Asini Corii Colla,Glycyrrhizae Radix et Rhizoma,Ginseng Radix et Rhizoma,Rehmanniae Radix,Paeoniae Radix Alba,Atractylodis Macrocephalae Rhizoma,Artemisiae Argyi Folium,Allii Fistulosi Bulbus,Scutellariae Radix,Rehmanniae Radix Praeparata,Poria,Taxilli Herba,and Dipsaci Radix. The high- frequency herbs usually exert the actionsof replenishing the deficient,and mainly have the sweet-warm properties and mostly have the meridian tropism ofthe liver,spleen and kidney meridians. The association rule analysis of the high-frequency herbs yielded a total of15 herbal combinations, and the herbal group of Angelicae Sinensis Radix and Chuanxiong Rhizoma had thehighest frequency being. The cluster analysis yielded 3 new formula combinations. Conclusion In the classicgynecological monographs of traditional Chinese gynecology, the herbs for the treatment of threatened abortionusually have the actions of replenishing the deficient,and are sweet-warm in the properties and mostly have themeridian tropism of the liver,spleen and kidney meridians. The treatment for threatened abortion can be achievedmainly by the methods of replenishing deficiency and strengthening thoroughfare vessel, replenishing qi andnourishing blood,and activating blood and removing stasis. And the medication for preventing miscarriage extertscertain characteristics. The medication rules can provide reference for the clinical treatment of threatened abortionin modern TCM.
作者
方昉
徐晓栋
廖慧慧
FANG Fang;XU Xiao-Dong;LIAO Hui-Hui(Hangzhou Fuyang Hospital of Traditional Chinese Medicine,Hangzhou 311400 Zhejiang,China;The First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510120 Guangdong,China)
出处
《广州中医药大学学报》
CAS
2023年第7期1832-1838,共7页
Journal of Guangzhou University of Traditional Chinese Medicine
关键词
先兆流产
中医妇科经典专著
当归
川芎
补虚固冲
益气养血
活血化瘀
数据挖掘
threatened abortion
classic monographs of traditional Chinese gynecology
Angelicae Sinensis Radix
Chuanxiong Rhizoma
replenishing deficiency and strengthening thoroughfare vessel
replenishing qi and nourishing blood
activating blood and removing stasis
data mining
