摘要
目的评价中药海绵外敷联合负压封闭引流(vacuum sealing drainage,VSD)治疗下肢静脉性溃疡的临床疗效与安全性。方法选取我院2019年6月—2021年12月收治的下肢静脉性溃疡患者68例,采用随机抽签法分为两组,治疗组与对照组各34例。对照组采用单纯负压封闭引流,治疗组在对照组基础上采用载有微米三七的白及胶海绵外敷,1次/日,疗程均为4周。观察两组患者的临床有效率、视觉模拟评分(visual analogue scales,VAS)、创面面积、静脉临床严重程度评分(venous clinical severity score,VCSS)以评价临床疗效,并记录两组发生的不良事件。结果治疗组的临床有效率为91.2%,对照组为64.7%,治疗组高于对照组,且两组差异有统计学意义(P<0.05);治疗后两组患者的VAS评分、创面面积、VCSS均较治疗前明显降低(P<0.05),且治疗组较对照组改善更明显(P<0.05),治疗期间两组均未发生不良事件。结论载有微米三七的白及胶海绵外敷联合VSD治疗下肢静脉性溃疡疗效显著,且安全性高,值得临床进一步推广应用。
Objective To evaluate the clinical efficacy and safety of traditional Chinese medicine sponge external application combined with vacuum sealing drainage(VSD)in the treatment of lower limb venous ulcers.Methods A total of 68 patients with lower limb venous ulcers admitted to our hospital from June 2019 to December 2021 were selected and randomly divided into two groups,with 34 cases in the treatment group and 34 cases in the control group.The control group was treated with simple negative pressure closure drainage,while the treatment group was treated with external application of a white gelatin sponge containing microns of Panax notoginseng,once a day,for 4 weeks.Observe the clinical efficacy,visual analog scale(VAS),wound area,and venous clinical severity score(VCSS)of two groups of patients to evaluate clinical efficacy,and record adverse events that occurred in both groups.Results The clinical effective rate of the treatment group was 91.2%,while the control group was 64.7%.The treatment group was higher than the control group,and the difference between the two groups was statistically significant(P<0.05);After treatment,the VAS score,wound area,and VCSS of the two groups of patients were significantly reduced compared to before treatment(P<0.05),and the treatment group showed more significant improvement compared to the control group(P<0.05).During the treatment period,no adverse events occurred in either group.Conclusion The combination of micronized Panax notoginseng sponge and VSD has a significant therapeutic effect and high safety in the treatment of lower limb venous ulcers,which is worthy of further clinical promotion and application.
作者
邓智雯
颉玙
毛乔
靳璐
张习禄
雷霆
DENG Zhiwen;JIE Yu;MAO Qiao;JIN Lu;ZHANG Xilu;LEI Ting(Affiliated Hospital of Shaanxi University of Chinese Medicine,Shaanxi Xianyang 712000,China)
出处
《陕西中医药大学学报》
2023年第4期100-104,共5页
Journal of Shaanxi University of Chinese Medicine
基金
陕西省自然科学基础研究计划项目(2021JM-474)
咸阳市科技计划项目(2018k02-95)。
关键词
下肢静脉性溃疡
中药敷料
负压封闭引流
创面愈合
白及
三七
Lower limb venous ulcer
Traditional Chinese medicine dressings
Vacuum sealing drainage
Wound healing
Baiji
Sanqi
