摘要
目的:建立小檗胺药物利用评价(DUE)标准,为小檗胺的临床合理应用提供参考和指导。方法:以小檗胺的药品说明书为基础,参考相关指南和文献,通过专家咨询法制订小檗胺DUE标准。采用回顾性研究方法,对2020年4月至2022年4月北京京煤集团总医院182例使用小檗胺的住院患者进行用药合理性评价,具体包括适应证、用法与用量、联合用药、禁忌证、疗效评价和不良反应等。结果:建立了小檗胺DUE标准,对纳入的182例病例进行用药合理性评价,其中完全符合评价标准的合理率为85.16%(155例),不合理率为14.84%(27例)。不合理用药主要为适应证不适宜(7例)、用法与用量不适宜(19例)以及适应证和用法与用量均不适宜(1例)。用药期间发生1例药品不良反应,表现为恶心、呕吐。结论:本研究建立的小檗胺DUE标准有较强的科学性、实用性和可行性,该院临床使用小檗胺时在适应证、用法与用量方面存在一些问题,可进一步优化。
OBJECTIVE:To establish the drug use evaluation(DUE)criteria of berbamine,so as to provide reference and guidance for rational clinical application of berbamine.METHODS:Based on the drug instructions of berbamine,relevant guidelines and literature were referred,the DUE criteria of berbamine was established accroding to expert consultation.A retrospective study method was used to evaluate the rationality of berbamine in 182 inpatients in Beijing Jingmei Group General Hospital from Apr.2020 to Apr.2022,including indications,usage and dosage,drug combination,contraindications,efficacy and adverse drug reactions.RESULTS:The DUE criteria of berberine was established,and the rationality of medication was evaluated in 182 cases,among which 85.16%(155 cases)of the cases fully met the evaluation criteria,and 14.84%(27 cases)of the cases were irrational.Irrational drug use mainly included unsuitable indications(7 cases),improper usage and dosage(19 cases),and improper indications and usage and dosage(1 case).One case of adverse drug reaction occurred during the treatment,which was manifested as nausea and vomiting.CONCLUSIONS:The DUE criteria of berbamine established in this study is scientific,practical and feasible.There are some problems in the indications,usage and dosage of berbamine in the clinical application of the hospital,which can be optimized.
作者
王丽丽
刘莹
胡海锦
陈世财
刘建平
王丽霞
张进华
WANG Lili;LIU Ying;HU Haijin;CHEN Shicai;LIU Jianping;WANG Lixia;ZHANG Jinhua(Dept.of Pharmacy,Beijing Jingmei Group General Hospital,Beijing 102300,China;Dept.of Pharmacy,Beijing Huairou District Hospital,Beijing 101400,China;Dept.of Pharmacy,Beijing North Asia Orthopaedic Hospital,Beijing 102445,China;Dept.of Pharmacy,Beijing Luhe Hospital,Beijing 101100,China;Dept.of Pharmacy,Guang’anmen Hospital of China Academy of Chinese Medical Sciences,Beijing 100053,China;Dept.of Pharmacy,Fujian Maternal and Child Health Care Hospital,Fuzhou 350000,China)
出处
《中国医院用药评价与分析》
2023年第6期741-743,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
基金
国家重点研发计划“中医药现代化研究”重点专项项目(No.2018YFC1707405)。
关键词
小檗胺
药物利用评价
专家咨询法
合理用药
Berbamine
Drug use evaluation
Expert consultation method
Rational drag use
