摘要
目的对比带状疱疹性神经痛患者应用氨酚双氢可待因与氨酚曲马多治疗的临床效果。方法120例带状疱疹性神经痛患者,根据治疗方式不同分为研究组和常规组,各60例。研究组给予氨酚双氢可待因治疗,常规组给予氨酚曲马多治疗。对比两组患者治疗前后数字疼痛评分法(NRS)评分、匹兹堡睡眠质量指数量表(PSQI)评分及疼痛缓解效果、不良反应发生情况。结果治疗前及治疗5 d后,两组NRS评分和PSQI评分组间对比,差异无统计学意义(P>0.05);治疗5 d后,两组NRS评分和PSQI评分均低于治疗前,差异有统计学意义(P<0.05)。研究组疼痛缓解总有效率95.00%与常规组的93.33%对比,差异无统计学意义(P>0.05)。研究组不良反应发生率为13.33%,显著低于常规组的30.00%,差异有统计学意义(P<0.05)。结论带状疱疹性神经痛患者应用氨酚双氢可待因与氨酚曲马多的镇痛疗效相当,但是氨酚双氢可待因不反应明显更少,安全性更高,可作为临床首选药物。
Objective To compare the clinical effect of paracetamol and dihydrocodeine tartrate and paracetamol and tramadol hydrochloride on herpes zoster neuralgia.Methods A total of 120 patients with herpes zoster neuralgia were divided into research group and conventional group according to different treatment methods,with 60 cases in each group.The research group was treated with paracetamol and dihydrocodeine tartrate,while the conventional group was treated with tramadol hydrochloride.The numerical rating scale(NRS)score and Pittsburgh Sleep Quality Index(PSQI)score before and after treatment,pain relief effect,and occurrence of adverse reactions were compared between the two groups.Results Before treatment and 5 d after treatment,there was no statistically significant difference in NRS score and PSQI score between the two groups(P>0.05).5 d after treatment,NRS score and PSQI score in both groups were lower than those before treatment in this group,and the difference was statistically significant(P<0.05).The total effective rate of pain relief was 95.00%in the research group,which was not statistically significant compared with 93.33%in the conventional group(P>0.05).The incidence of adverse reactions was 13.33%in the research group,which was significantly lower than that of 30.00%in the conventional group,and the difference was statistically significant(P<0.05).Conclusion The analgesic efficacy of paracetamol and dihydrocodeine tartrate and tramadol hydrochloride in patients with herpes zoster neuralgia is comparable,but paracetamol and dihydrocodeine tartrate has significantly fewer adverse reaction and higher safety,and can be the preferred drug in clinical practice.
作者
黄世明
卿帅
肖敏
衣起山
HUANG Shi-ming;QING Shuai;XIAO Min(Pain Department,Yibin First People's Hospital,Yibin 644000,China)
出处
《中国实用医药》
2023年第14期123-125,共3页
China Practical Medicine
关键词
带状疱疹性神经痛
氨酚双氢可待因
氨酚曲马多
Herpes zoster neuralgia
Paracetamol and dihydrocodeine tartrate
Tramadol hydrochloride
