摘要
目的:比较胸腺基质淋巴细胞生成素(TSLP)、小气道肺功能指标单独或联合检测对咳嗽变异性哮喘(CVA)的临床诊断价值。方法:选择2019年1月至2021年4月于漯河市中心医院就诊的85例CVA患者设为CVA组,慢性咳嗽患儿42例设为non-CVA组。ELISA检测外周血中TSLP水平,肺功能分析仪检测小气道肺功能指标[肺活量的最大中段呼气流量(MMEF)、75%肺活量的最大呼气流速(MEF 75)、MEF 50和MEF 25]。比较两组间的TSLP水平和小气道肺功能检测参数,分析TSLP值与小气道肺功能指标的相关性,比较TSLP、小气道肺功能指标单独或联合诊断CVA的临床价值。结果:CVA组TSLP水平高于non-CVA组,MMEF、MEF 75、MEF 50和MEF 25水平低于non-CVA组,两组间比较差异有统计学意义(P<0.05)。CVA组中TSLP值与MMEF、MEF 75、MEF 50和MEF 25均呈负相关(r=−0.551,P<0.001;r=−0.473,P<0.001;r=−0.685,P<0.001;r=−0.347,P=0.001)。TSLP联合MMEF诊断CVA的临床价值高于TSLP和MMEF单独检测(Z=3.415,P=0.014;Z=3.624,P=0.010),TSLP联合MEF 50诊断CVA的临床价值高于TSLP和MEF 50单独检测(Z=4.215,P=0.007;Z=4.523,P=0.003)。结论:TSLP联合MMEF或MEF 50诊断CVA的临床价值高于单独检测,具有一定的临床使用价值。
Objective:To compare the clinical diagnostic value of thymic stromal lymphopoietin(TSLP)and small airway lung function indicators alone or in combination for cough variant asthma(CVA).Methods:A total of 85 CVA patients in Luohe Central Hospital from January 2019 to April 2021 were selected as CVA group,and 42 children with chronic cough as non-CVA group.ELISA was used to detect TSLP level in peripheral blood,and pulmonary function analyzer was used to detect small airway lung function indi-cators[maximum midstream expiratory flow rate of vital capacity(MMEF),maximum expiratory flow rate of 75%vital capacity(MEF 75),MEF 50 and MEF 25].TSLP level and small airway lung function test parameters between two groups were compared,correla-tion between TSLP value and small airway lung function indexes was analyzed,and clinical value of TSLP and small airway lung function indexes alone or in combination in diagnosis of CVA were compared.Results:Level of TSLP in CVA group was higher than that in nonCVA group,and levels of MMEF,MEF 75,MEF 50 and MEF 25 were lower than those in non-CVA group,there was statistical differ-ences between two groups(P<0.05).TSLP value in CVA group was negatively correlated with MMEF,MEF 75,MEF 50 and MEF 25(r=−0.551,P<0.001;r=−0.473,P<0.001;r=−0.685,P<0.001;r=−0.347,P=0.001).Clinical value of TSLP combined with MMEF in diagnosis of CVA was higher than that of TSLP and MMEF alone(Z=3.415,P=0.014;Z=3.624,P=0.010).Clinical value of TSLP combined with MEF 50 in diagnosis of CVA was higher than that of TSLP and MEF 50 alone(Z=4.215,P=0.007;Z=4.523,P=0.003).Conclusion:Clinical value of TSLP combined with MMEF or MEF 50 in diagnosis of CVA is higher than that of single detec-tion,and it has certain clinical value.
作者
晁婵
CHAO Chan(Department of Pediatric,Luohe Central Hospital,Luohe 462000,China)
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2023年第7期1490-1493,共4页
Chinese Journal of Immunology
