摘要
目的 探讨非小细胞肺癌(NSCLC)组织中细胞角蛋白5/6(CK5/6)的表达及与临床病理特征和预后的相关性。方法 收集52例NSCLC患者的临床资料,检测其CK5/6表达情况,并比较不同临床病理特征者癌组织CK5/6表达差异。以1年为观察终点,比较不同癌组织CK5/6表达者总生存及无瘤生存情况。结果52例中22例癌组织CK5/6表达阳性,阳性率为42.31%。年龄≥65岁、有吸烟史、组织类型为鳞癌、低分化、淋巴结转移及TNM分期Ⅲ~Ⅳ期者癌组织CK5/6表达阳性率更高(均P <0.05)。肺鳞癌CK5/6表达阳性与表达阴性者1年总生存率、1年无瘤生存率及无瘤生存时间差异均无统计学意义(均P> 0.05)。肺腺癌CK5/6表达阳性者1年无瘤生存率、无瘤生存时间均低于表达阴性者(均P <0.05)。结论 CK5/6的表达不仅与NSCLC组织类型、恶性程度有关,还能辅助预测肺腺癌不良预后,指导临床诊疗。
Objective To explore the expression of cytokeratin 5/6(CK5/6) in non-small cell lung cancer(NSCLC)tissues and its correlation with clinicopathological characteristics and prognosis.Methods The clinical data of 52patients with NSCLC were collected.The CK5/6 expression was detected,and the difference in CK5/6 expression was compared among different clinicopathological characteristics.With one year as the observation end-point,the overall survival and tumor-free survival were compared among patients with different CK5/6 expressions in cancer tissues.Results Among 52 cases,CK5/6 expression was positive in cancer tissues of 22 cases,with positive rate of42.31%.The positive rate of CK5/6 expression was higher in cancer tissues of patients with age≥65 years old,history of smoking,tissue type of squamous cell carcinoma,low differentiation,lymph node metastasis and TNM stage Ⅲ-Ⅳ(all P 0.05).Among patients with squamous cell lung carcinoma,there were no statistically significant differences in one year overall survival rate,one year tumor-free survival rate and tumor-free survival time between patients with positive and negative CK5/6 expression(all P 0.05).Among patients with lung adenocarcinoma,the one year tumor-free survival rate and tumor-free survival time of patients with positive CK5/6 expression were lower or shorter than those of patients with negative expression(all P 0.05).Conclusions The expression of CK5/6 is not only related to the tissue type and malignancy degree of NSCLC,but also can help predict the poor prognosis of lung adenocarcinoma and guide the clinical diagnosis and treatment.
作者
郑伊平
陈献国
徐小义
李献帅
支倩雯
章艳斐
ZHENG Yiping;CHEN Xianguo;XU Xiaoyi;LI Xianshuai;ZHI Qianwen;ZHANG Yanfei(Jinhua Municipal Central Hospital,Jinhua 321000,Zhejiang,China)
出处
《现代实用医学》
2023年第7期849-852,共4页
Modern Practical Medicine
基金
金华市科技计划项目(2021-3-085)。
关键词
非小细胞肺癌
CK5/6
鳞癌
腺癌
预后
Non-small cell lung cancer
CK5/6
Squamous cell carcinoma
Adenocarcinoma
Prognosis
