摘要
目的:探讨桃红四物汤加减联合手法复位夹板外固定术治疗桡骨远端骨折的效果及对骨折修复因子的影响。方法:选取2020年1月—2021年12月甘肃临夏州中医医院收治的86例桡骨远端骨折患者,应用随机数字表法将其分为对照组及观察组,各43例。对照组采用手法复位夹板外固定治疗,观察组在对照组基础上联合桃红四物汤加减治疗。对比两组患者的术后恢复指标、腕关节解剖学指标、骨折修复因子及骨代谢指标。结果:观察组的消肿时间、止痛时间、瘀斑消失时间及骨折愈合时间均短于对照组,差异均有统计学意义(P<0.05)。治疗前,两组的掌倾角、尺偏角、桡骨短缩值比较,差异均无统计学意义(P>0.05);治疗后,两组的掌倾角及尺偏角均增加,观察组均高于对照组,桡骨短缩值均降低,观察组低于对照组,差异均有统计学意义(P<0.05)。治疗前,两组的血清血管内皮生长因子(VEGF)、骨形成蛋白-2(BMP-2)、转化生长因子-β1(TGF-β1)水平比较,差异均无统计学意义(P>0.05);治疗后,两组的各项指标均升高,观察组均高于对照组,差异均有统计学意义(P<0.05)。治疗前,两组的25-羟基维生素D[25-(OH)D]、β胶原特殊序列(β-Crossl)、抗酒石酸酸性磷酸酶-5b(TRACP-5b)、总Ⅰ型胶原氨基端延长肽(tP1NP)及骨钙素(BGP)水平比较,差异均无统计学意义(P>0.05);治疗后,两组的25-(OH)D、tP1NP及BGP水平均升高,观察组均高于对照组,β-Crossl、TRACP-5b水平均降低,观察组均低于对照组,差异均有统计学意义(P<0.05)。结论:桃红四物汤加减联合手法复位夹板外固定术可缩短桡骨远端骨折的愈合时间,改善腕关节功能、促进骨折修复、纠正骨代谢异常,效果显著。
Objective:To investigate the effect of modified Taohong Siwu Decoction combined with manual repositioning splint external fixation in the treatment of distal radius fractures and the effect on fracture repair factors.Method:A total of eighty-six patients with distal radius fractures admitted to Linxia Hui Autonomous Prefecture Hospital of Traditional Chinese Medicine from January 2020 to December 2021 were selected and divided into observation group and control group using random number table method,with 43 cases in each group.The control group was treated with external fixation by manual repositioning splint,and the observation group was treated with modified Taohong Siwu Decoction on the basis of the control group.The postoperative recovery indexes,wrist joint anatomical indexes,fracture repair factors and bone metabolism indexes of the two groups were compared.Result:The swelling reduction time,pain relief time,bruise disappearance time and fracture healing time in the observation group were shorter than those in the control group,the differences were statistically significant(P<0.05).Before treatment,there were no statistically significant differences in the palmar inclination angle,ulnar deviation angle and radial shortening values between the two groups(P>0.05);after treatment,the palmar inclination angle and ulnar deviation angle of the two groups were increased,and those of the observation group were higher than those of the control group,the radial shortening value was reduced,and that of the observation group was lower than that of the control group,the differences were statistically significant(P<0.05).Before treatment,the levels of serum vascular endothelial growth factor(VEGF),bone forming protein-2(BMP-2)and transforming growth factor-β1(TGF-β1)were compared between the two groups,the differences were no statistically significant(P>0.05);after treatment,the indexes in both groups were increased,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in the levels of 25-hydroxyvitamin D[25-(OH)D],β-collagen special sequence(β-Crossl),anti-tartrate acid phosphatase-5b(TRACP-5b),total type I collagen amino-terminal prolongation peptide(tP1NP)and osteocalcin(BGP)between the two groups(P>0.05);after treatment,the levels of 25-(OH)D,tP1NP and BGP levels in both groups increased,and those of the observation group were higher than those of the control group,andβ-Crossl,TRACP-5b levels decreased,and the observation group were lower than those of the control group,the differences were statistically significant(P<0.05).Conclusion:Modified Taohong Siwu Decoction combined with manual repositioning splint external fixation can shorten the healing time of distal radius fracture,improve wrist joint function,promote fracture repair and correct bone metabolism abnormalities with significant effect.
作者
司子杰
SI Zijie(Linxia Hui Autonomous Prefecture Hospital of Traditional Chinese Medicine,Gansu Province,Linxia 731100,China)
出处
《中国医学创新》
CAS
2023年第22期81-85,共5页
Medical Innovation of China
关键词
桡骨远端骨折
手法复位夹板外固定术
桃红四物汤
腕关节
骨折修复因子
骨代谢
Distal radius fracture
External fixation with manipulative repositioning splint
Modified
Taohong Siwu Decoction
Wrist joint
Fracture repair factor
Bone metabolism
