摘要
目的:观察益生菌联合谷氨酰胺强化肠内营养支持治疗重症急性胰腺炎(SAP)患者的效果。方法:选取2019年1月至2022年8月该院收治的90例SAP患者进行前瞻性研究,按双色球随机法将其分为对照组和观察组各45例。对照组采用谷氨酰胺强化肠内营养支持治疗,观察组在对照组基础上联合益生菌治疗,比较两组治疗前后肠黏膜屏障功能指标[血清内毒素、二胺氧化酶(DAO)、D-乳酸]水平、肠道菌群变化、血清炎性因子[C反应蛋白(CRP)、白细胞介素-6(IL-6)]水平,以及不良反应发生率。结果:治疗后,两组血清内毒素、DAO、D-乳酸、CRP和IL-6水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组乳酸杆菌、双歧杆菌数量均多于治疗前,且观察组多于对照组,两组肠杆菌、肠球菌数量均少于治疗前,且观察组少于对照组,差异有统计学意义(P<0.05);两组治疗期间均未见明显药物相关不良反应。结论:益生菌联合谷氨酰胺强化肠内营养支持治疗SAP患者可改善肠黏膜屏障功能,调节肠道菌群,抑制炎症反应,效果优于单纯谷氨酰胺强化肠内营养支持治疗。
Objective:To observe effects of Probiotics combined with Glutamine-enhanced enteral nutrition support on patients with severe acute pancreatitis(SAP).Methods:A prospective study was conducted on 90 patients with SAP admitted to the hospital from January 2019 to August 2022.They were divided into control group and observation group according to the two-color ball randomization method,45 cases in each group.The control group was treated with Glutamine-enhanced enteral nutrition support,while the observation group was treated with Probiotics on the basis of that of the control group.The levels of intestinal mucosal barrier function indexes[serum endotoxin,diamine oxidase(DAO),D-lactic acid],the intestinal flora,the serum inflammatory factor levels[C-reactive protein(CRP),interleukin-6(IL-6)],and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:After the treatment,the levels of serum endotoxin,DAO,D-lactic acid,CRP and IL-6 in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the numbers of Lactobacillus and Bifidobacterium in the two groups were more than those before the treatment,and that in the observation group was more than that in the control group;the numbers of Enterobacter and Enterococcus in the two groups were less than those before the treatment,and that in the observation group was less than that in the control group;and the difference was statistically significant(P<0.05).No obvious drug-related adverse reactions were found in the two groups during the treatment.Conclusions:Probiotics combined with Glutamine-enhanced enteral nutrition support for the SAP patients can improve the intestinal mucosal barrier function,regulate the intestinal flora,and inhibit the inflammatory reactions.Moreover,it is superior to single Glutamine-enhanced enteral nutrition support.
作者
苏晋簇
廖成术
SU Jincu;LIAO Chengshu(Department of Gastroenterology of Datian County General Hospital,Sanming 366100 Fujian,China)
出处
《中国民康医学》
2023年第13期50-52,共3页
Medical Journal of Chinese People’s Health
关键词
重症急性胰腺炎
益生菌
谷氨酰胺
肠内营养
肠黏膜屏障功能
肠道菌群
炎性因子
Severe acute pancreatitis
Probiotics
Glutamine
Enteral nutrition
Intestinal mucosal barrier function
Intestinal flora
Inflammatory factor
