摘要
近年来,随着人们生活水平的改变和老龄化现象日趋严重,中枢神经系统退行性疾病的发病率愈来愈高,其病因尚不明确,严重影响患者的生活质量,增加社会和患者家庭的经济负担。因此,寻找一种新药治疗该类疾病已成为研究热点。原花青素(procyanidins,PCs)具有抗氧化、抗凋亡、抗炎、抗癌以及神经保护等作用,提示PCs具有多靶点的药理作用。正因如此,PCs作为一种天然抗氧化剂引起了广泛的关注,并且已应用于神经系统疾病动物模型的治疗。现基于国内外学者对PCs药理作用的研究现状,本文综述了PCs在防治中枢神经系统退行性疾病中的作用及机制的研究进展,提出了PCs治疗中枢神经系统退行性疾病可能与抑制铁死亡有关的观点。
In recent years,with the change of people's living standards and the increasingly serious aging phenomenon,the incidence of degenerative diseases of the central nervous system is increasing.Due to the unknown etiology,such diseases seriously affect the quality of life of patients and increase the economic burden of the society and patients' families.Therefore,finding a new drug to treat this kind of disease has become a research hotspot.Procyanidins(PCs) have antioxidant,anti-apoptotic,anti-inflammatory,anticancer and neuroprotective effects,suggesting that PCs have multi-target pharmacological effects.Because of this,PCs have attracted extensive attention as natural antioxidants and have been applied in the treatment of animal models of nervous system diseases.Based on the current status of research on the pharmacological effects of PCs by domestic and foreign scholars,this paper reviews the research progress in the role and mechanism of PCs in the prevention and treatment of degenerative diseases of central nervous system and puts forward the view that PCs may be related to the inhibition of iron death in the treatment of degenerative diseases of central nervous system.
作者
姚子萌
陈蕾
孙小荣
黄杰
董淑英
YAO Zi-meng;CHEN Lei;SUN Xiao-rong;HUANG Jie;DONG Shu-ying(Department of Pharmacology,School of Pharmacy,Bengbu Medical College,Bengbu 233030,China;Basic and Clinical Key Laboratory of Cardiovascular and Cerebrovascular Diseases,Bengbu Medical College,Bengbu 233030,China)
出处
《中国新药杂志》
CAS
CSCD
北大核心
2023年第14期1432-1437,共6页
Chinese Journal of New Drugs
基金
国家自然科学基金资助项目(81402930)
安徽高校自然科学研究资助项目(KJ2021A0688)
蚌埠医学院“512人才培养计划”资助项目(BY51201104)。
关键词
原花青素
中枢神经系统退行性疾病
药理作用
多靶点作用
procyanidins
degenerative diseases of central nervous system
pharmacological actions
multi-target effect
