摘要
目的 对比分析围绝经期异常子宫出血患者接受曼月乐和地屈孕酮片治疗后的效果。方法 前瞻性选取2019年10月—2021年12月玉环市人民医院门诊收治的临床表现为围绝经期异常子宫出血的患者100例为研究对象,随机分为对照组(采用屈孕酮片治疗,50例)和观察组(采用曼月乐治疗,50例),对比两组患者治疗效果,观察患者治疗前后子宫内膜厚度、血红蛋白水平、性激素及不良反应的差异。结果 治疗后,观察组患者治疗总有效率(98.00%)高于对照组(72.00%),差异有统计学意义(χ^(2)=2.910,P<0.05)。治疗后,观察组患者体内雌二醇[(218.54±13.85)pmol/L]、黄体生成素[(8.54±1.22)U/L]及卵泡刺激素[(8.59±0.59)U/L]水平均低于对照组[(352.85±15.65)pmol/L、(9.99±1.56)U/L及(10.08±0.92)U/L],差异均有统计学意义(t=45.444、5.177及9.640,均P<0.05)。观察组患者子宫内膜厚度[(3.51±0.61)mm]低于对照组[(6.51±1.35)mm],血红蛋白水平[(115.57±13.44)g/L]高于对照组[(92.65±12.58)g/L],差异均有统计学意义(t=14.463、8.804,均P<0.05)。对照组患者出现头晕3例、腹痛2例、阴道流血4例,不良反应发生率为18.00%;观察组患者出现腹痛1例、阴道流血1例,不良反应发生率为4.00%。观察组不良反应发生率低于对照组(χ^(2)=6.775,P<0.05)。结论 围绝经期异常子宫出血患者给予曼月乐治疗,患者各项指标改善更为明显,疗效显著,临床应用价值更高。
Objective To compare and analyze the therapeutic effects of mirena and dydrogesterone tablets on patients with abnormal uterine bleeding during perimenopause.Methods A prospective study was conducted on 100 patients with abnormal uterine bleeding during the perimenopausal period admitted to the outpatient department of Yuhuan People's Hospital from October 2019 to December 2021.They were randomly divided into the control group(50 cases treated with dydrogesterone tablets) and observation group(50 cases treated with mirena).The therapeutic effects of the two groups of patients were compared,and the endometrial thickness,hemoglobin levels before and after treatment were observed Differences in sex hormones and adverse reactions.Results After treatment,the total effective rate of the observed patients(98.00%) was higher than that of the control group(72.00%),with a statistically significant difference(χ^(2)=2.910,P<0.05).After treatment,the levels of estradiol[(218.54±13.85)ρmol/L],luteinizing hormone[(8.54±1.22)U/L],and follicle stimulating hormone[(8.59±0.59)U/L] in the observation group were lower than those in the control group[(352.85±15.65)ρmol/L,(9.99±1.56)U/L and(10.08±0.92)U/L],and the differences were statistically significant(t=45.444,5.177 and 9.640,all P<0.05).The endometrial thickness of the observation group[(3.51±0.61)mm] was lower than that of the control group[(6.51±1.35)mm],and the hemoglobin level[(115.57±13.44)g/L] was higher than that of the control group[(92.65±12.58)g/L],with statistical significance(t=14.463,8.804,all P<0.05).There were 3 cases of dizziness,2 cases of abdominal pain,and 4 cases of vaginal bleeding in the control group,with an adverse reaction rate of 18.00%;There was 1 case of abdominal pain and 1 case of vaginal bleeding in the observation group,with an adverse reaction rate of 4.00%.The incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(χ^(2)=6.775,P<0.05).Conclusion Patients with abnormal uterine bleeding during the perimenopausal period are treated with Manyule,and the improvement of various indicators is more significant.The therapeutic effect is significant,and the clinical application value is higher.
作者
李倩
叶天华
郑素霞
LI Qian;YE Tian-hua;ZHENG Su-xia(Department of Gynecology,Yuhuan People's Hospital,Zhejiang 317600,China)
出处
《中国妇幼保健》
CAS
2023年第15期2891-2894,共4页
Maternal and Child Health Care of China
基金
浙江省玉环市科技计划项目(201905)。
关键词
曼月乐
围绝经期
异常子宫出血
地屈孕酮片
Mirena
Perimenopausal period
Abnormal uterine bleeding
Dydrogesterone tablets
