摘要
目的探究血小板与淋巴细胞比值(PLR)联合全身炎症反应指数(SIRI)对非肌层浸润性膀胱肿瘤等离子电切术后复发的预测价值。方法2020年1月~2021年6月我院收治的非肌层浸润性膀胱肿瘤病人108例,等离子电切术治疗前24小时内检测病人中性粒细胞、淋巴细胞、血小板、单核细胞水平,并计算SIRI和PLR值,术后随访12个月,根据复发结局分为复发组和未复发组。分析非肌层浸润性膀胱肿瘤病人术后复发的影响因素,绘制受试者工作特征曲线(ROC),采用曲线下面积(AUC)评估PLR、SIRI对非肌层浸润性膀胱肿瘤病人术后复发的预测效能。结果截止随访结束,108例非肌层浸润性膀胱肿瘤病人中失访7例,随访率93.52%。复发16例,复发率15.84%,其余85例(84.16%)病人均未复发。复发组年龄、SIRI、PLR和肿瘤分期T1期、肿瘤多发、危险程度高危占比大于未复发组,差异有统计学意义(P<0.05)。Logistic分析显示,高龄、肿瘤分期T1期、肿瘤多发、危险程度高危、SIRI和PLR值升高均是非肌层浸润性膀胱肿瘤病人术后复发的危险因素(P<0.05)。ROC分析结果显示,SIRI、PLR值单一及联合预测非肌层浸润性膀胱肿瘤病人术后复发的AUC分别为0.748(95%CI:0.640~0.855)、0.790(95%CI:0.669~0.911)、0.819(95%CI:0.713~0.925)。结论SIRI、PLR可用于预测非肌层浸润性膀胱肿瘤病人术后复发的风险,且预测效能良好。
Objective To explore the predictive value of platelet lymphocyte ratio(PLR)combined with systemic inflammatory response index(SIRI)in the recurrence of non muscle invasive bladder tumor after plasma resection.Methods From January 2020 to June 2021,108 patients with nonmuscular invasive bladder tumor were treated in Hai’an People’s Hospital.The levels of neutrophils,lymphocytes,platelets,and monocytes were detected within 24 hours before plasma electroresection,and the SIRI and PLR levels were calculated.The patients were followed up for 12 months and divided into relapse group and non relapse group according to the recurrence outcome.To analyze the influencing factors of postoperative recurrence of patients with nonmuscular invasive bladder tumor,draw the ROC,and use the area under the curve(AUC)to evaluate the predictive efficacy of PLR and SIRI on postoperative recurrence of patients with nonmuscular invasive bladder tumor.Results By the end of follow-up,7 of 108 patients with nonmuscular invasive bladder tumors had lost follow-up,with a follow-up rate of 93.52%.16 cases recurred,the recurrence rate was 15.84%,and 85 cases(84.16%)had no recurrence detected.The age,SIRI,PLR,tumor stage T1,multiple tumors,and high risk ratio in the recurrence group were higher than those in the non recurrence group(P<0.05).Logistic analysis showed that older age,tumor stage T1,multiple tumors,high risk degree,elevated SIRI and PLR levels were all risk factors for postoperative recurrence of patients with nonmuscular invasive bladder tumor(P<0.05).ROC analysis showed that AUC of patients with nonmuscular invasive bladder tumor predicted by single and combined SIRI and PLR levels were 0.748(95%CI:0.640~0.855),0.790(95%CI:0.669~0.911)and 0.819(95%CI:0.713~0.925)respectively.Conclusion SIRI and PLR can be used to predict the risk of postoperative recurrence in patients with nonmuscular invasive bladder tumor,and the prediction effect is good.
作者
彭建明
徐卫东
罗玉根
董圳
PENG Jianming;XU Weidong;LUO Yugen;DONG Zhen(Department of Urology,Hai'an People's Hospital,Jiangsu,Nantong 226600,China)
出处
《临床外科杂志》
2023年第7期673-676,共4页
Journal of Clinical Surgery
