摘要
以聚乳酸(PLA)及氢溴酸高乌甲素(LAH)为原料,采用静电纺丝技术制备不同PLA浓度的PLA微/纳米纤维膜及不同LAH含量的PLA/LAH复合微/纳米纤维膜,研究了纤维膜的表面形貌、化学结构、力学性能、药物缓释性能及抗炎性能。结果表明:当PLA浓度为120 mg/mL时,PLA微/纳米纤维膜的纤维直径分布均匀,平均直径达1.4μm,具有较高比表面积和高孔隙率,拉伸应力最大,达3.168 MPa;添加LAH后,纤维膜的纤维直径和形貌未发生明显改变,PLA与LAH之间是物理结合,并未发生化学反应;随着LAH含量的增加,PLA/LAH复合微/纳米纤维膜的累积药物释放率增加,当LAH质量分数为14%时累积药物释放率最高,达89%,具有良好的药物缓释性能;二甲苯致小鼠耳廓肿胀试验表明LAH质量分数为14%的PLA/LAH复合微/纳米纤维膜具有优异的抗炎效果,二甲苯致小鼠耳廓的肿胀度为4.90 mg。
Using polylactic acid(PLA)and lappaconitine hydrobromic acid(LAH)as raw materials,PLA micro/nanofiber membranes with different PLA concentrations and PLA/LAH composite micro/nanofiber membranes with different LAH contents were prepared by electrospinning process.The surface morphology,chemical structure,mechanical properties,drug release and anti-inflammatory properties of the fiber membrane were studied.The results showed that PLA micro/nanofiber membrane had a uniform fiber diameter distribution with an average diameter of 1.4μm and possessed a relatively high specific surface area,a high porosity and a tensile stress maximum of 3.168 MPa when the PLA concentration was 120 mg/mL;the fiber diameter and morphology of the fiber membrane did not significantly change,a physical binding formed between PLA and LAH and no chemical reaction occurred after adding LAH;the cumulative drug release rate of PLA/LAH composite micro/nanofiber membrane was increased with the increase of LAH content,and was maximized as 89%when the LAH mass fraction was 14%,indicating a good drug release performance;and the xylene induced mouse ear swelling test showed that PLA/LAH composite micro/nanofiber membrane with a LAH mass fraction of 14%had an excellent anti-inflammatory effect and swelling degree of mouse ears caused by xylene of 4.90 mg.
作者
王灿灿
陈乐乐
李正逗
陈霞
杜欣芮
姜飞飞
张继
WANG Cancan;CHEN Lele;LI Zhengdou;CHEN Xia;DU Xinrui;JIANG Feifei;ZHANG Ji(College of Life Science,Northwest Normal University,Lanzhou 730070;Engineering Technology Research Center of Gansu Characteristic Plant Active Ingredient Products,Lanzhou 730070;Institute of New Rural Development,Northwest Normal University,Lanzhou 730070)
出处
《合成纤维工业》
CAS
2023年第4期14-19,共6页
China Synthetic Fiber Industry
基金
国家自然科学基金(51873175)
甘肃省引导科技创新发展专项基金(2019ZX-05)。
关键词
聚乳酸纤维
氢溴酸高乌甲素
静电纺丝
微/纳米纤维膜
抗炎性能
polylactic acid fiber
lappaconitine hydrobromide
electrospinning
micro/nanofiber membrane
anti-inflammatory properties
