摘要
动脉粥样硬化(atherosclerosis,AS)是一种以脂肪、胆固醇和炎性免疫细胞形成等为特征的斑块过度积累的慢性血管病变。淋巴管作为将脂质、炎性物质和组织液引流的通道,参与AS动脉内膜脂质堆积、血管炎症反应及内膜增生等多个病理过程,成为AS研究的新靶点。该文主要对淋巴管在AS各病理环节中的作用及相关中西药干预进行讨论,旨在从淋巴管角度为中西药防治AS提供可行性思路。
Atherosclerosis(AS)is a chronic vascular disease characterized by excessive accumulation of plaques formed by fat,cholesterol and inflammatory immune cells.Lymphatic vessels,as channels for the drainage of lipids,inflammatory substances and tissue fluids,are involved in multiple pathological processes such as lipid accumulation in the intima of AS arteries,vascular inflammation and intimal hyperplasia,and have become a new target for AS research.This article mainly discusses the role of lymphatic vessels in each pathological link of AS and related Chinese and western medicine interventions,aiming to provide feasible ideas for preventing and treating AS with Chinese and western medicines from the view of lymphatic vessels.
作者
孙鑫
吴鸿飞
SUN Xin;WU Hong-fei(School of Pharmacy,Anhui University of Chinese Medicine,Key Laboratory of Research and Development of Traditional Chinese Medicine in Anhui Province,Hefei 230012,China)
出处
《中国药理学通报》
CAS
CSCD
北大核心
2023年第9期1618-1622,共5页
Chinese Pharmacological Bulletin
基金
国家自然科学基金资助项目(No 82274137,81873038)
安徽省自然科学基金资助项目(No 2208085MH275)
安徽高校自然科学研究项目(No KJ2021A0592)
安徽省高校杰出青年项目(No 2022AH020041)。
关键词
淋巴管
淋巴瓣膜
淋巴引流
动脉粥样硬化
中西药
调控机制
lymphatic vessel
lymphatic valve
lymphatic drainagea
atherosclerosis
Chinese and western medicine
regulatory mechanism
