摘要
目的:探讨丁苯酞氯化钠注射液联合抗血小板药物在急性脑梗死治疗中的应用价值。方法:抽取2020年6月至2021年9月安阳市第六人民医院收治的急性脑梗死患者82例,按随机数字表法分为研究组与对照组,每组41例。对照组采用抗血小板药物治疗,研究组采用丁苯酞氯化钠注射液联合抗血小板药物治疗。对比两组临床效果、血液流变学、美国国立卫生研究院脑卒中量表(NIHSS)评分、Barthel指数(BI)、简易智力状态检查量表(MMSE)评分、蒙特利尔认知功能评估量表(MOCA)评分及不良反应发生率。结果:研究组总有效率(95.12%,39/41)高于对照组(75.61%,31/41),差异有统计学意义(P<0.05)。研究组血浆黏度、红细胞压积低于对照组(P<0.05);研究组NIHSS评分低于对照组,BI指数高于对照组(P<0.05);治疗后,研究组MMSE、MoCA评分高于对照组(P<0.05)。研究组不良反应发生率(7.32%,3/41)与对照组(9.76%,4/41)比较差异未见统计学意义(P>0.05)。结论:丁苯酞氯化钠注射液联合抗血小板药物在急性脑梗死治疗中可提高临床疗效,改善血液流变学,提高患者的神经功能、认知功能和生活自理能力,存在安全性。
Objective To investigate the application value of butylphthalide and sodium chloride injection combined with antiplatelet drugs in the treatment of acute cerebral infarction.Methods A total of 82 patients with acute cerebral infarction treated in the Anyang People's Hospital NO.6 from June 2020 to September 2021 were selected,and they were divided into study group and control group according to random number table method,with 41 cases in each group.The control group was treated with antiplatelet drugs,and the study group was treated with butylphthalide and sodium chloride injection combined with antiplatelet drugs.The clinical effect,hemorheology,American National Institutes of Health Stroke Scale(NIHSS)score,Barthel index(BI),mini-mental state examination scale(MMSE)score,Montreal cognitive function assessment scale(MOCA)score and incidence of adverse reactions were compared between the two groups.Results The total effective rate of the study group(95.12%,39/41)was higher than that of the control group(75.61%,31/41),P<0.05.The plasma viscosity and hematocrit of the study group were lower than those of the control group(P<0.05).The NIHSS score of the study group was lower than that of the control group,and the BI was higher than that of the control group(P<0.05).After treatment,scores of MMSE and MoCA in the study group were higher than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the study group(7.32%,3/41)and control group(9.76%,4/41),P>0.05.Conclusions Butylphthalide and sodium chloride injection combined with antiplatelet drugs can improve clinical efficacy,ameliorate hemorheology,improve neurological function,cognitive function,and self-care ability in the treatment of acute cerebral infarction,with safety.
作者
郑东焕
任会菊
高园园
Zheng Donghuan;Ren HuiJu;Gao Yuanyuan(Department of Neurology,Anyang People's Hospital N0.6,Anyang 455000,China)
出处
《中国实用医刊》
2023年第9期109-112,共4页
Chinese Journal of Practical Medicine
关键词
脑梗死
丁苯酞氯化钠注射液
抗血小板药物
Cerebral infarction
Butylphthalide and sodium chloride injection
Antiplatelet drugs
