摘要
卵巢癌(OvCa)、原发性卵巢功能不全(POI)和多囊卵巢综合征(PCOS)是常见的女性卵巢疾病。卵巢疾病具有异质性特点,因此其诊断难,治疗效果及预后较差。肾母细胞瘤基因1(WT1)是一种具有抑癌和促癌双重作用的特殊基因,其编码蛋白通过激活或抑制基因转录调节卵巢细胞的增殖、分化和迁移等过程。WT1突变或表达异常会影响OvCa、POI、PCOS等疾病的发生发展,其与卵巢疾病的关联表明该基因可作为靶点,在诊断、治疗、预后评估方面具有潜力。笔者主要总结WT1在卵巢疾病发生和发展中的调控机制,讨论WT1在卵巢疾病诊断、治疗和预后方面的应用潜力。
Ovarian cancer(OvCa),premature ovarian insufficiency(POI),and polycystic ovary syndrome(PCOS)are all ovarian diseases affecting females.Due to the variability of ovarian diseases,they are challenging to identify and have poor prognosis and therapeutic effect.Wilms′tumor gene 1(WT1)is a unique gene that can both suppress and promote cancer.By activating or inhibiting gene transcription,the WT1 coding protein regulates ovarian cell proliferation,differentiation,migration,and other processes.WT1 mutations and abnormal expression impact the onset and progression of OvCa,POI,PCOS,and other diseases.Because WT1 is linked to ovarian diseases,it can be targeted for diagnosis,treatment,and prognosis assessment.This article summarizes WT1′s regulatory mechanism in the occurrence and development of ovarian diseases and discusses its potential application in the diagnosis,treatment,and prognosis of ovarian disease.
作者
刘育昕
王子晗
张艺馨
栾永婕
孟凯
Liu Yuxin;Wang Zihan;Zhang Yixin;Luan Yongjie;Meng Kai(College of Second Clinical Medicine,Jining Medical University,Jining 272067,China;Collaborative Innovation Center for Birth Defect Research and Transformation of Shandong Province,Jining 272067,China)
出处
《中华诊断学电子杂志》
2023年第3期178-183,共6页
Chinese Journal of Diagnostics(Electronic Edition)
基金
山东省自然科学基金(ZR2020QH042)
济宁医学院大学生创新创业训练计划项目(cx2021038)。
