摘要
喹唑啉类化合物是一类重要的杂环骨架,普遍存在于各种有机分子和生物碱中。由于其丰富的生物学活性和药理作用,开发其绿色的合成新方法具有重要的意义。报道了以醛类化合物和2-氨基二苯甲酮衍生物为底物,以乙酸铵为氮源,在[Bmim]BF 4催化下合成喹唑啉类化合物的新方法。在最佳反应条件下,以中等至优异的产率合成了22个喹唑啉类化合物,并采用^(1)HNMR、^(13)CNMR对目标产物进行了结构鉴定。该方法无需使用有机溶剂,具有合成方法简单、反应产率高、底物范围广泛等优点,为喹唑啉类化合物的合成提供了新的思路。
Quinazoline compounds are important heterocyclic skeletons,which are widely present in various organic molecules and alkaloids.Due to its rich biological activities and pharmacological effects,it is of great significance to develop a new and green method to construct this structure.A novel method has been developed for the preparation of quinazoline compounds by the reaction of using aldehydes and 2-aminobenzophenones as substrates and ammonium acetate as nitrogen source under the catalysis of[Bmim]BF_(4).Under the best reaction conditions,22 different quinazoline derivatives were synthesized with moderate to excellent yields.The structures of the target products were characterized by^(1)HNMR and ^(13)CNMR.This method has the advantages of solvent-free,simple synthesis method,high reaction yield and wide range of substrates,which provides a new idea for the synthesis of quinazoline compounds.
作者
庞钰琪
应乐天
牟硕
马雪
陈雪柔
孙武积
钟启迪
PANG Yu-qi;YING Le-tian;MU Shuo;MA Xue;CHEN Xue-rou;SUN Wu-ji;ZHONG Qi-di(School of Pharmacy,North China University of Science and Technology,Tangshan 063000,China)
出处
《化学试剂》
CAS
北大核心
2023年第9期11-18,共8页
Chemical Reagents
基金
河北省自然科学基金项目(B2021209007)
河北省大学生创新创业训练计划项目(T2022056)。
