摘要
目的分析重症肺炎患者病原体分布与中医证候分型之间的关系。方法选择2021年10月至2022年9月天津大学天津医院收治的37例重症肺炎患者作为研究对象。通过宏基因组二代测序(mNGS)进行病原体检测,分析不同中医证候分型重症肺炎患者的病原体分布情况。结果共纳入37例重症肺炎患者,其中痰热壅肺证16例(43.24%),热陷心包证6例(16.22%),邪陷正脱证5例(13.51%),气阴两虚证4例(10.81%),痰湿阻肺证3例(8.11%),肺脾气虚证3例(8.11%);患者感染的病原体类型、病原体类型种数与中医证候分型之间差异无统计学意义(P>0.05);肺炎克雷伯菌感染与痰热壅肺证之间差异有统计学意义(χ^(2)=9.306,P=0.003)。结论重症肺炎患者感染病原体类型及病原体类型数量与其中医证候分型无明显关系,肺炎克雷伯菌感染与痰热壅肺证型关系密切。
Objective To analyze the relationship between pathogens distribution and traditional Chinese medicine(TCM)syndrome classification in patients with severe pneumonia.Methods A total of 37 patients with severe pneumonia admitted to Tianjin Hospital from October 2021 to September 2022 were selected as the research subjects.Pathogen detection was performed using metagenomic next-generation sequencing(mNGS),and the pathogen distribution of severe pneumonia patients with different TCM syndromes classification was analyzed.Results Among the 37 patients with severe pneumonia,there were 16 cases of lung phlegm heat syndrome(43.24%),6 cases of heattrapping pericardial syndrome(16.22%),5 cases of interior invasion of pathogen and vital qi collapse syndrome(13.51%),4 cases of qi-yin deficiency syndrome(10.81%),3 cases of phlegm-dampness accumulated in the lung syndrome(8.11%),and 3 cases of lung-spleen qi deficiency syndrome(8.11%).There was no statistically significant difference in the type and number of pathogen infections among different TCM syndromes classification(P>0.05).However,there was a statistically significant difference between Klebsiella pneumoniae infection and phlegm-heat obstructing the lung syndrome(χ^(2)=9.306,P=0.003).Conclusion There is no significant relationship between the type and number of pathogen infections and TCM syndrome classification in patients with severe pneumonia.However,Klebsiella pneumoniae infection is closely related to lung phlegm heat syndrome.
作者
于国玮
李玉叶
王秋义
胡鹏
张磊
赵春玲
任亚茹
刘美蓉
Yu Guowei;Li Yuye;Wang Qiuyi;Hu Peng;Zhang Lei;Zhao Chunling;Ren Yaru;Liu Meirong(Department of Infectious Diseases,Tianjin Hospital,Tianjin 300211,China;Department of Respiratory Medicine,Binhai Hospital of Traditional Chinese Medicine,Tianjin 300451,China;Department of Internal Medicine Intensive Care Unit,Tianjin Hospital,Tianjin 300211,China;Department of Nephrology,Tianjin Hospital,Tianjin 300211,China)
出处
《中国中西医结合急救杂志》
CAS
CSCD
北大核心
2023年第3期277-281,共5页
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
基金
天津市卫生健康委天津市中医药管理局中医中西医结合科研课题(2021158)。
关键词
宏基因组二代测序
重症肺炎
病原体
中医证候分型
Metagenomic next-generation sequencing
Severe pneumonia
Pathogen
Traditional Chinese medicine syndrome classification
