摘要
Dear Editor,Microtubules consisting of α/β-tubulin dimers exhibit various shapes in different cell stages and cell types,which are important for their diverse roles in eukaryotic cells.Both α-and β-tubulin comprise multiple genes in vertebrates,e.g.mice have at least seven α-tubulin and eight β-tubulin genes.The distribution and expression of these isotypes vary widely among different tissues and developmental stages.Tubulin α1A is generally expressed in post-mitotic neurons and exhibits a decrease in postnatal and adult stages(Yue et al.,2014),while tubulin α4A is highly expressed in the brain and heart during later stages of development(Yue et al.,2014).
基金
supported by grants from the National Natural Science Foundation of China(31991194 and 31330046)
the Special Fundfor Science-Technology InnovationStrategy of Guangdong Province(2021B0909050004).
