摘要
目的分析急性缺血性脑卒中患者血小板计数与白细胞计数、颈动脉狭窄及卒中严重程度的相关性。方法回顾性分析2018年2月至2021年3月首都医科大学附属北京友谊医院连续收治的445例急性缺血性脑卒中患者的血生化和临床资料,血小板计数分为≥300×10^(9)/L组(增高组)和血小板计数正常组[(100~300)×10^(9)/L],比较两组患者实验室指标及颈动脉狭窄和卒中严重程度,采用Pearson法分析血小板计数与颈动脉狭窄、卒中发病时和第14天美国国立卫生研究院卒中量表(NIHSS)评分的相关性。结果增高组患者血白细胞计数和中性粒细胞绝对值分别为(8.06±1.80)×10^(9)/L、5.50±1.57,明显高于正常组[(7.01±2.24)×10^(9)/L、4.64±2.03],差异均有统计学意义(P<0.05)。增高组颈动脉重度狭窄及闭塞患者的比率为87.27%,明显高于正常组(39.49%),差异有统计学意义(P<0.05)。增高组患者卒中发病时和第14天的NIHSS评分分别为(12.98±4.17)、(9.98±3.37)分,均明显高于正常组[(3.43±1.71)、(2.98±1.36)分],差异均有统计学意义(P<0.05)。Pearson分析可见,血小板计数与颈内动脉狭窄比例、卒中后入院时、卒中第14天的NIHSS评分均呈正相关性(r=0.547、0.455、0.407,P<0.05)。结论急性缺血性脑卒中患者血小板计数高于正常者。血小板计数增高患者白细胞计数和中性粒细胞绝对值明显增高;血小板计数增高与急性缺血性脑卒中患者颈内动脉狭窄程度、卒中严重程度呈正相关。
Objective To analyze the correlation between platelet count and white blood cell count,carotid artery stenosis and stroke severity in patients with acute ischemic stroke.Methods Laboratory and clinical data of 445 patients with acute ischemic stroke admitted to Beijing Friendship Hospital,Capital Medical University from February 2018 to March 2021 were retrospectively analyzed.According to platelet count,they were divided into≥300×10^(9)/L group(increased group)and normal group[(100-300)×10^(9)/L].Laboratory data,carotid artery stenosis and stroke severity were compared between the two groups.Pearson method was used to analyze the correlation between platelet count and carotid artery stenosis and National Institutes of Health Stroke Scale(NIHSS)score at the onset and 14th day after stroke.Results The total number of white blood cells and absolute value of neutrophil in patients with increased platelet count group were(8.06±1.80)×10^(9)/L,5.50±1.57,respectively,which were significantly higher than those in patients with normal platelet count group[(7.01±2.24)×10^(9)/L,4.64±2.03],the differences were statistically significant(P<0.05).The proportion of patients with severe carotid artery stenosis and occlusion in the elevated group was 87.27%,which was significantly higher than that in the normal group(39.49%),the difference was statistically significant(P<0.05).The NIHSS scores of patients in the increased platelet count group at the onset and 14th day after stroke were(12.98±4.17),(9.98±3.37)points,respectively,which were significantly higher than those in the normal group[(3.43±1.71),(2.98±1.36)points],the differences were statistically significant(P<0.05).Pearson analysis showed a positive correlation between platelet count and the proportion of internal carotid artery stenosis,as well as the NIHSS score at admission after stroke and on the 14th day after stroke(r=0.547,0.455,0.407,P<0.05).Conclusion The platelet count of patients with acute ischemic stroke is higher than that of normal individuals.Patients with increased platelet count showed a significant increase in white blood cell count and absolute neutrophil count.Elevated platelet count is positively correlated with the degree of internal carotid artery stenosis and stroke severity in patients with acute ischemic stroke.
作者
晏立娜
杨毅
张拥波
赵莹莹
YAN Li-na;YANG Yi;ZHANG Yong-bo(Department of Neurology,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China;Department of Neurology,Pinggu Hospital,Beijing Friendship Hospital,Beijing 101200,China)
出处
《临床和实验医学杂志》
2023年第16期1695-1699,共5页
Journal of Clinical and Experimental Medicine
基金
北京市医院管理中心青年人才培养“青苗”计划资助。
关键词
血小板计数
急性缺血性脑卒中
白细胞计数
相关性
颈动脉狭窄
神经功能评分
Platelet count
Acute ischemic stroke
White blood cell count
Correlation
Carotid artery stenosis
Neurological function score
