摘要
目的探究双合汤治疗痰浊瘀阻证老年慢性阻塞性肺疾病急性加重(acute exacerbation of chronic obstructive pulmonary disease,AECOPD)的临床效果。方法选择该院2019年1月—2021年12月收治的80例痰浊瘀阻证老年AECOPD患者,按照随机数字表分为联合组和常规组,两组各40例,比较两组患者临床疗效、中医证候积分、血常规指标、血气指标及不良反应。结果治疗后,联合组临床治疗效果优于常规组(P<0.05);两组老年AECOPD患者咳嗽气喘、胸闷刺痛、痰多色白、舌质紫黯等中医证候积分较治疗前显著降低,联合组显著低于常规组(P<0.05);两组老年AECOPD患者动脉血氧分压(PaO_(2))较治疗前升高,联合组显著高于常规组(P<0.05),中性粒细胞与淋巴细胞比率(NLR)、血小板与淋巴细胞比率(PLR)、红细胞分布宽度(RDW)、二氧化碳分压(PaCO_(2))较治疗前降低,联合组显著低于常规组(P<0.05)。两组老年AECOPD患者不良反应差异无统计学意义(P>0.05)。结论老年AECOPD患者在西医治疗基础上联用双合汤可显著提高临床治疗效果,缓解临床症状,改善血常规和血气指标,且安全性良好。
Objective To investigate the clinical effect of Shuanghe Decoction(双合汤)in the treatment of acute exacerbation of chronic obstructive pulmonary disease(AECOPD)with turbid-phlegm and stasis syndrome in the elderly.Methods A total of 80 elderly patients with AECOPD and turbid-phlegm and blood stasis syndrome who were admitted to the hospital from January 2019 to December 2021 were selected.The patients were divided into combined group and routine group by random number table method,with 40 cases in each group.The patients in the routine group were treated with routine western medicine,and those in the combined group were treated with Shuanghe Decoction on this basis.The two groups were compared in terms of clinical effect,TCM syndrome scores,blood routine,blood gas indicators,and adverse reactions.Results The clinical effect in the combined group was better than that in the routine group(P<0.05).After treatment,the scores for TCM syndromes such as cough or asthma,chest tightness and stabbing pain,excessive white phlegm and dark purple tongue decreased,and the combined group had significantly lower scores than the routine group(P<0.05).After treatment,arterial partial pressure of oxygen(PaO_(2))in the two groups increased,and PaO_(2) in the combined group was significantly higher than that in the routine group(P<0.05).The neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR),red blood cell distribution width(RDW)and partial pressure of carbon dioxide(PaCO_(2))in the two group decreased,and these indicators in the combined group were significantly lower than those in the routine group(P<0.05).There was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion Shuanghe Decoction combined with western medicine is effective in the treatment of elderly patients with AECOPD,which can significantly improve the clinical effect,relieve clinical symptoms and improve blood routine and blood gas indicators,with good safety.
作者
金方有
耿克兆
朱国盛
JIN Fangyou;GENG Kezhao;ZHU Guosheng(Pharmacy Department,Tianchang Hospital of Traditional Chinese Medicine,Tianchang 239300,Anhui,China)
出处
《辽宁中医杂志》
CAS
2023年第8期176-179,共4页
Liaoning Journal of Traditional Chinese Medicine
关键词
老年
慢性阻塞性肺疾病
急性加重期
双合汤
痰浊瘀阻证
elderly
chronic obstructive pulmonary disease
acute exacerbation
Shuanghe Decoction(双合汤)
turbid-phlegm and blood stasis syndrome
