摘要
目的观察妊高征(妊娠期高血压综合征)合并胎盘早剥患者分临床特征,探讨其临床治疗效果。方法于2018年02月———2023年02月河南科技大学附属许昌市中心医院妇产科收治82例妊高征合并胎盘早剥患者作为临床观察对象,运用数字随机表法给予对照观察,常规组(给予常规对症治疗)、治疗组(给予常规对症治疗同时加用硫酸镁、拉贝洛尔),各41例。观察记录两组临床特征,比较总有效率、总产程时间、产后出血量、炎症应激指标[CRP(C反应蛋白)、内皮素(ET)、丙二醛(MDA)]、妊娠分娩结局、不良反应。结果26例轻度胎盘早剥、32例中度胎盘早剥、24例重度胎盘早剥;以阴道异常出血、腹部疼痛不适为主要特征。治疗组总有效率较常规组更高(P<0.05)。治疗组总产程时间较常规组更短,产后出血量、CRP、ET、MDA较常规组更低(P<0.05)。治疗组胎死腹中、剖宫率以及不良反应发生率较常规组更低(P<0.05)。结论妊高征合并胎盘早剥的特征较为明显,给予硫酸镁、拉贝洛尔辅助治疗的临床效果更佳,能够显著减轻炎症应激反应,改善妊娠分娩结局,减少不良反应的发生。
Objective To observe the clinical characteristics of patients with pregnancy-induced hypertension(PIH)complicated with placental abruption,and to explore its clinical therapeutic effect.Methods From February,2022 to February,2023,totally 82 cases of pregnancy-induced hypertension complicated with placental abruption were treated as clinical observation objects,and the control observation was made by the method of digital random table,with 41 cases in the routine group(given routine symptomatic treatment)and the treatment group(given routine symptomatic treatment plus magnesium sulfate and labetalol).The clinical features of the two groups were observed and recorded,and the total effective rate,total labor time,postpartum hemorrhage,inflammatory stress indicators[CRP(C-reactive protein),endothelin(ET),malondialdehyde(MDA)],pregnancy and delivery outcome and adverse reactions were compared.Results There were 26 cases of mild placental abruption,32 cases of moderate placental abruption and 24 cases of severe placental abruption.It is mainly characterized by abnormal vaginal bleeding and abdominal pain and discomfort.The total effective rate of the treatment group was higher than that of the routine group(P<0.05).The total labor time in the treatment group was shorter than that of the routine group,and the postpartum hemorrhage,CRP,ET and MDA were lower than those of the routine group(P<0.05).The rates of stillbirth,cesarean section and adverse reactions in the treatment group were lower than those of the routine group(P<0.05).Conclusion The characteristics of pregnancy-induced hypertension complicated with placental abruption are obvious,and the clinical effect of adjuvant treatment with magnesium sulfate and labetalol is better,which can significantly reduce inflammatory stress reaction,improve pregnancy delivery outcome and reduce the occurrence of adverse reactions.
作者
刘孟霞
曹蒙
王雪勤
LIU Meng-xia;CAO Meng;WANG Xue-qin(Xuchang Central Hospital Affiliated to Henan University of Science and Technology,Xuchang,Henan 461000,China)
出处
《医药论坛杂志》
2023年第14期10-13,18,共5页
Journal of Medical Forum
关键词
妊高征
胎盘早剥
分娩结局
临床特征
不良反应
Pregnancy-induced hypertension
Placental abruption
Delivery outcome
Clinical features
Adverse effect
