摘要
目的总结由感染继发的可逆性胼胝体压部病变综合征(reversible splenial lesion syndrome,RESLES)患者的临床特征。方法纳入2016年1月至202110月九江学院附属医院收治的由感染继发的RESLES患者6例,其中男5例,女1例,年龄16~48岁,平均(33.6±11.4)岁。回顾性分析6例患者的临床表现、实验室检查、影像学检查、治疗和预后的资料。结果6例患者中临床表现为发热5例,头痛4例,癫痫发作3例,咳嗽、肌痛1例,意识障碍1例。6例患者T2WI呈高信号,DWI呈高信号,病灶均无强化,5例患者胼胝体压部T1WI呈低信号,随访时胼胝体压部的异常信号好转或消失。3例患者接受抗病毒联合糖皮质激素治疗,另外3例患者接受抗生素治疗,经治疗6例患者症状均痊愈或明显好转。结论感染继发的RESLES临床表现多样,以发热最多见,针对病原体治疗后预后均良好。
Objective To investigated the clinical features of reversible splenial lesion syndrome(RESLES)secondary to infection.Methods Six patients were diagnosed with RESLES secondary to infection admitted to Jiujiang University Affiliated Hospital from January 2016 to October 2021 were collected,including 5 males and 1 female,with an average of(33.6±11.4)years(age range:16-48 years).We retrospectively reviewed the clinical features,laboratory tests,magnetic resonance imaging(MRI)results,treatments,and prognosis of six patients.Results Among the 6 cases,5 cases had a fever,4 cases had a headache,3 cases had seizures,1 case had cough and myalgia,and 1 case had consciousness disturbance.Six patients'MRI showed hyperintensity on T2WI,DWI in the splenium of corpus callosum,without significant gadolinium enhancement.Five patients'MRI showed low signal intensity on T1WI in the splenium of corpus callosum,which disappeared at follow-up.Three patients were treated with antivirus and glucocorticoids,and the other 3 received antibiotic treatment.All patients showed significant improvement with the symptoms.Conclusions RESLES secondary to infection has heterogeneous clinical manifestations,and fever is the most common symptoms,the prognosis of the disease is favorable in most of the cases after treatment for pathogen.
作者
索一君
夏忠斌
吴向斌
鲍兵
SUO Yijun;XIA Zhongbin;WU Xiangbin;BAO Bing(不详;Department of Neurology,Jiujiang University Affiliated Hospital,Jiujiang Jiangxi 332000,China)
出处
《中国神经免疫学和神经病学杂志》
CAS
北大核心
2023年第5期321-325,共5页
Chinese Journal of Neuroimmunology and Neurology
基金
国家自然科学基金资助项目(No.82260454)
江西省卫生健康委科技计划项目(No.202212006)
九江市科技计划项目(No.S2021QNZZ022)。
关键词
可逆性胼胝体压部病变综合征
胼胝体压部
感染
reversible splenial lesion syndrome
splenium of the corpus callosum
infection
