摘要
目的探讨增损三甲汤加味对中风后遗症患者神经功能、运动功能以及血液流变学的影响。方法选取南阳张仲景医院2021年3月至2022年4月入院治疗的中风后遗症患者72例,以随机数字表法将患者分为三甲汤组与对照组。其中三甲汤组患者38例采取增损三甲汤加味治疗,对照组患者34例采取西药常规治疗。比较两组治疗前后病患血液流变学和血脂变化情况;比较两组治疗前和治疗后1个月、2个月、3个月后神经功能、运动功能以及日常生活活动能力;对比两组不良反应发生率。结果相较于治疗前,两组治疗3个月后的血浆粘度、全血高切及低切黏度、红细胞压积(Hct)、纤维蛋白原(FIB)、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)均显著降低,高密度脂蛋白胆固醇(HDL-C)显著升高,且三甲汤组全血高切黏度、全血低切黏度、Hct、FIB、TG、TC、LDL-C明显更低,差异有统计学意义(P<0.05);相较于治疗前,两组治疗后1个月、2个月、3个月美国国立卫生院卒中量表(NIHSS)评分显著降低,Fugl-Meyer运动功能评分量表(FMA)及日常生活活动能力评定量表(ADL)评分均显著升高,且三甲汤组NIHSS评分明显更低,FMA、ADL评分明显更高,差异有统计学意义(P<0.05);两组患者不良反应率对比,差异无统计学意义(P>0.05)。结论采用增损三甲汤加味治疗中风后遗症患者,有助于改善患者神经、运动等各项功能,提高其日常生活能力,且患者血液流变学和血脂等指标得到明显改善,其不良反应率无明显增高。
Objective To explore the effect of modified Zengsun Sanjia decoction on neurological function,motor function,and hemorheology in patients with stroke sequelae.Methods A total of 72 patients with stroke sequelae admitted for treatment from March 2021 to April 2022 were selected and randomly divided into the Sanjia decoction group and the control group using a random number table method.Among them,38 patients in the Sanjia decoction group were treated with modified Sanjia decoction,while 34 patients in the control group were treated with conventional Western medicine.The changes in blood rheology and blood lipids between the two groups of patients before and after treatment were compared;The neurological function,motor function,and daily living activities of the two groups before and after 1,2,and 3 months of treatment were compared;The incidence of adverse reactions between the two groups was compared.Results Compared with before treatment,the plasma viscosity,whole blood high shear and low shear viscosity,hematocrit(Hct),fibrinogen(FIB),triglycerides(TG),total cholesterol(TC),and low-density lipoprotein cholesterol(LDL-C)in both groups were significantly reduced after 3 months of treatment,high density lipoprotein cholesterol(HDL-C)was significantly increased,and the whole blood high shear viscosity,whole blood low shear viscosity,Hct,FIB,TG,TC LDL-C was significantly lower and the difference was statistically significant(P<0.05);Compared to before treatment,the two groups showed a significant decrease in the National Institutes of Health Stroke Scale(NIHSS)scores at 1 month,2 months,and 3 months after treatment,while the Fugl-Meyer Motor Function Rating Scale(FMA)and Activity of Daily Living Rating Scale(ADL)scores were significantly increased.Moreover,the Sanjia decoction group had significantly lower NIHSS scores,significantly higher FMA and ADL scores,and the difference was statistically significant(P<0.05);There was no statistically significant difference in adverse reaction rates between the two groups of patients(P>0.05).Conclusion The use of modified Zengsun Sanjia decoction to treat stroke sequelae patients can help improve their neurological,motor and other functions,enhance their daily living ability,and significantly improve their hemorheology and blood lipid indicators,with no significant increase in their adverse reaction rate.
作者
孙晓莽
马锐
常晓
郭伟霞
王聪
霍松
SUN Xiaomang;MA Rui;CHANG Xiao;GUO Weixia;WANG Cong;HUO Song(Department of Neurology,ZHANG Zhongjing Hospital,Nanyang,Nanyang Henan 473000,China;Department Ⅰ of Internal Medicine,ZHANG Zhongjing Hospital,Nanyang,Nanyang Henan 473000,China;Department of Acupuncture,ZHANG Zhongjing Hospital,Nanyang,Nanyang Henan 473000,China)
出处
《临床研究》
2023年第10期12-15,共4页
Clinical Research
关键词
增损三甲汤加味
中风后遗症
神经功能
血液流变学
modified Zengsun Sanjia decoction
stroke sequelae
neurological function
hemorheology
