摘要
目的比较隔药灸贴与艾灸对神经根型颈椎病(CSR)肝肾不足证患者疼痛、麻木、颈部活动受限的临床疗效及对血浆白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)的影响。方法采用随机数字表法将62例患者分为观察组和对照组各31例。对照组采用常规艾灸法,选取关元、双侧足三里、双侧三阴交、大椎,30 min/次,3次/周;观察组采用温阳扶正膏进行隔药灸贴治疗,取穴同对照组,4 h/次,3次/周。2组均治疗2周。观察2组临床疗效,比较2组治疗前后Northwick Park颈痛量表(NPQ)评分、简化McGill疼痛问卷(SF-MPQ)评分、中医症状积分及血浆IL-6、TNF-α水平,记录2组治疗过程中发生的不良反应。结果观察组总有效率为96.8%(30/31),高于对照组的87.1%(27/31),观察组显效率为51.6%(16/31),高于对照组的29.0%(9/31),2组比较差异均有统计学意义(P<0.05)。与本组治疗前比较,2组治疗后NPQ评分、SF-MPQ评分、中医症状积分及血浆IL-6、TNF-α水平均下降(P<0.05);2组治疗后比较,观察组NPQ评分、SF-MPQ评分、中医症状积分及血浆IL-6、TNF-α水平均低于对照组(P<0.05)。观察组1例患者在贴敷隔药灸贴2 h后皮肤出现发红瘙痒现象,其他患者未见不良反应。结论温阳扶正膏隔药灸贴治疗能有效改善CSR肝肾不足证患者疼痛、麻木等症状和中医证候,疗效优于常规艾灸法,其机制可能与有效抑制炎症因子IL-6、TNF-α水平相关。
Objective To compare the effects of medicine-separated moxibustion plaster and moxibustion on pain,numbness and neck movement limitation in patients with cervical spondylotic radiculopathy(CSR)with liverkidney deficiency syndrome and the effects of IL-6,TNF-αconcentrations in plasma.Methods Totally 62 patients with CSR of liver-kidney deficiency syndrome were randomly divided into observation group and control group,with 31 cases in each group.The control group was treated with moxibustion,and Guanyuan(CV4),Zusanli(ST36),Sanyinjiao(SP6)and Dazhui(GV14)were selected as the acupoints,30 minutes each time,3 times a week.In the observation group,Wenyang Fuzheng Ointment was selected for medicine-separated moxibustion plaster treatment,and the selection of acupoints was the same as the control group,4 hours each time,3 times a week.For 2 weeks in both groups.The clinical efficacy of the two groups was observed,and the scores of Northwick Park neck pain questionaire(NPQ),short-form McGill Pain Questionnaire(SF-MPQ),TCM symptom score,IL-6 and TNF-αcontents before and after treatment were compared between the two groups.The adverse reactions occurred during treatment were recorded.Results The total effective rate was 96.8%(30/31)in the observation group,which was higher than 87.1%(27/31)in the control group(P<0.05).The effective rate was 51.6%(16/31)in the observation group,which was higher than 29.0%(9/31)in the control group,with statistical significance(P<0.05).Compared with before treatment,NPQ scores,SF-MPQ scores,TCM symptom scores,and plasma IL-6 and TNF-αlevels decreased after treatment in both groups(P<0.05).After treatment,the NPQ score,SF-MPQ score,TCM symptom score,plasma IL-6 and TNF-αlevels in the observation group were lower than those in the control group(P<0.05).One patient in the observation group experienced redness and itching on the skin after applying herbal moxibustion for 2 hours,while no adverse reactions were observed in the other patients.Conclusion Wenyang Fuzheng Ointmentseparated moxibustion plaster can effectively improve the pain,numbness and other symptoms and TCM syndromes in patients with CSR liver-kidney deficiency syndrome,and the curative effect is better than ordinary moxibustion.The mechanism may be related to the effective inhibition on the levels of inflammatory factors IL-6 and TNF-α.
作者
王巧芸
徐芳园
张文超
赵峥嵘
黄伟
WANG Qiaoyun;XU Fangyuan;ZHANG Wenchao;ZHAO Zhengrong;HUANG Wei(Hubei University of Chinese Medicine,Hubei Provincial Collaborative Innovation Center of Preventive Treatment by Acupuncture and Moxibustion,Wuhan 430061,China;Hubei Hospital of Traditional Chinese Medicine Affiliated to Hubei University of Chinese Medicine,Wuhan 430061,China)
出处
《中国中医药信息杂志》
CAS
CSCD
2023年第10期168-172,共5页
Chinese Journal of Information on Traditional Chinese Medicine
基金
国家中医药管理局岐黄工程项目(2018年)
国家中医药管理局“中医药古籍文献和特色技术传承专项”项目(GZY-KJS-2020-078)
湖北省第二届医学领军人才工程培养对象暨湖北名医工作室项目(2019年)
湖北省中医院首批昙华林名医、学子培养项目(2018年)
武汉中青年医学骨干人才培养工程(2018年)。
关键词
神经根型颈椎病
肝肾不足证
隔药灸贴
艾灸
cervical spondylotic radiculopathy
liver-kidney deficiency syndrome
medicine-separated moxibustion plaster
moxibustion
