摘要
目的探讨阴道乳杆菌活菌制剂与局部抗真菌药物联合应用治疗外阴阴道假丝酵母菌病(vulvovaginal candidiasis,VVC)合并细菌性阴道炎(bacterial vaginosis,BV)混合感染的有效性及复发情况,探讨VVC合并BV的合适治疗方案。方法选取2019年1月~2021年1月上海市青浦区朱家角人民医院妇科门诊诊断为VVC合并BV患者164例。随机将患者分为两组,单药组79例,给予单纯局部用硝呋太尔制霉菌素阴道栓治疗;联合组85例,给予阴道局部硝呋太尔制霉菌素栓联合延华胶囊治疗,统计两组的治愈率、有效率及复发率。结果VVC合并BV治疗前后两组患者症状体征、复发率差异无统计学意义,治愈率、有效率差异有统计学意义(P<0.05)。第1次复查时,乳酸杆菌分级差异有统计学意义(P<0.05)。结论乳杆菌制剂与硝呋太尔制霉菌素阴道栓联合用药治疗VVC合并BV可达到更高的有效率和治愈率,联合用药效果更佳,但长期复发率无明显改善。
Objective To investigate the efficacy and recurrence of vaginal Lactobacillus prep⁃arations combined with topical antifungal drugs in the treatment of vulvovaginal candidiasis(VVC)complicated with bacterial vaginosis(BV)mixed infection,and to explore the appro⁃priate treatment plan for VVC complicated with BV.Methods A total of 164 patients diag⁃nosed as VVC complicated with BV in the gynecological outpatient department of Shanghai Qingpu District Zhujiajiao People’s Hospital from January 2019 to January 2021 were selected.The patients were randomly divided into two groups,79 cases in the single⁃drug group were giv⁃en only topical nifuratel nystatin vaginal suppository treatment,and 85 cases in the combination group were given vaginal topical nifuratel nystatin suppository combined with Yanhua capsules for treatment.The cure rate,effective rate and recurrence rate of the two groups were ana⁃lyzed.Results There were no significant differences in symptoms and recurrence rate between the two groups before and after VVC complicated with BV treatment,but there were statistically differences in cure rate and effective rate(P<0.05).There was a statistically difference in the grading of Lactobacillus between the two groups at the first re⁃examination(P<0.05).Conclusion Lactobacillus preparations combined with nifuratel nystatin vaginal suppository in the treatment of VVC complicated with BV can achieve higher effective rate and cure rate,and the combination effect is better.However,it has no significant improvement in the long term recurrence rate.
作者
姚虹
陆芹洁
YAO Hong;LU Qin-jie(Department of Gynecology,Changji People’s Hospital of Xinjiang,Changji 831100,Chi-na;Department of Gynecology,Shanghai Qingpu District Zhujiajiao People’s Hospital,Shanghai 201713,China)
出处
《哈尔滨医科大学学报》
CAS
2023年第3期289-292,共4页
Journal of Harbin Medical University
