摘要
特发性肺纤维化(IPF)病因尚未明确,治疗手段有限,具有严重致命性,现已成为广受关注的公共卫生问题。“肺生血”是指肺脏具有促进血液化生、推动血液输布的功能。“金水相生”理论认为,肺金与肾水生理上相生互滋,病理上相互影响。文章从“金水相生”角度出发,以肺、肾二脏和气、血、水三者为介,阐述“肺生血”功能的理论内涵。结合中医学和现代医学研究进展,从IPF发病机制和方药治疗效应两个方面展开论述,以肺肾相关的病机观与治疗观为切入点,揭示“肺生血”与IPF的效应机制,以期为IPF辨证施治提供新思路,为遣方用药提供新依据。
Idiopathic pulmonary fibrosis(IPF)has become a public health problem of widespread concern because of its unclear etiology,limited treatment methods and serious lethality.‘Lung generates blood’refers to the function of the lungs in promoting blood generation and circulation.The theory of'mutual generation between metal and water'suggests that lung and kidney nourish each other physiologically and influence each other pathologically.From the theory of'mutual generation between metal and water',the connotation of lung generates blood'is elaborated by the lungs and kidneys with their regulation in qi,blood,and water.Based on the research progress of traditional Chinese medicine and modern medicine,this article discussed the pathogenesis and the therapeutic effect of prescription for IPF.With the connection between lungs and kidneys in pathogenesis and therapeutic view as the breakthrough point,we revealed the effect mechanism between‘lung generates blood’and IPF to provide new ideas for the treatment of IPF based on syndrome differentiation and provide a new basis for dispatching prescriptions anddrugs.
作者
梁元钰
吕晓东
庞立健
董野
臧凝子
刘勇明
王靖宇
盛野
LIANG Yuanyu;LYU Xiaodong;PANG Lijian;DONG Ye;ZANG Ningzi;LIU Yongming;WANG Jingyu;SHENG Ye(Liaoning University of Traditional Chinese Medicine,Shenyang 110847,China;Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,China)
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2023年第10期4645-4649,共5页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
国家自然科学基金面上项目(No.82274440)
国家自然科学基金青年科学基金项目(No.82004294,No.82204993,No.82204787)
辽宁省科技厅中央引导地方科技发展资金(No.2023JH6/100100025)
辽宁省科技厅创新能力提升联合基金(No.2022-NLTS-13-03)
辽宁省教育厅重点项目(No.L202067)
辽宁省教育厅青年科技人才“育苗”项目(No.L202029)
辽宁中医药大学自然科学类重点项目(No.2021LZY040)。
关键词
特发性肺纤维化
金水相生
肺生血
肺虚络瘀
肺肾相关
Idiopathic pulmonary fibrosis
Mutual generation between metal and water
Lung generates blood
Lung deficiency and collateral blood stasis
Lung-kidney correlation
