摘要
目的 研讨多囊卵巢综合征合并2型糖尿病选择雌激素+孕激素周期疗法、二甲双胍联合治疗的价值。方法 选取2022年3月—2023年3月山东省菏泽市牡丹人民医院多囊卵巢综合征合并2型糖尿病患者60例为研究对象,采用数表法随机分组。观察组30例,实施雌、孕激素联合周期疗法+阿卡波糖片。对照组30例,实施雌、孕激素联合周期疗法+二甲双胍。对比两组血清性激素水平、代谢水平、排卵及妊娠情况、并发症发生率。结果 治疗后,观察组血清睾酮、黄体生成素、黄体生成素/卵泡刺激素、雌二醇水平显著低于对照组,差异有统计学意义(P<0.05)。观察组空腹胰岛素、空腹血糖、胰岛素抵抗指数低于对照组,差异有统计学意义(P<0.05)。观察组排卵率、妊娠率显著高于对照组,差异有统计学意义(P<0.05)。观察组流产率显著低于对照组,差异无统计学意义(P>0.05)。观察组并发症发生率显著高于对照组(16.67%vs 13.33%),差异无统计学意义(P>0.05)。结论 雌、孕激素联合周期疗法与二甲双胍联合应用于多囊卵巢综合征合并2型糖尿病治疗,可切实改善患者病症指标,能够实现患者妊娠率及排卵率的提升,且用药安全性较好。
Objective To study the value of estrogen+progesterone cycle therapy and metformin combination therapy for polycystic ovary syndrome complicated with type 2 diabetes mellitus.Methods From March 2022 to March 2023,60 patients with polycystic ovary syndrome complicated with type 2 diabetes were selected from Mudan People's Hospital of Heze City,Shandong Province,and they were randomly divided into groups using a digital table method.The observation group of 30 patients received combined estrogen and progesterone cyclic therapy+acarbose tablets.In the control group,30 patients received combined cyclic therapy of estrogen and progesterone+metformin.The serum sex hormone levels,metabolic levels,ovulation and pregnancy status,and complication rates were compared between the two groups.Results After treatment,the serum levels of testosterone,luteinizing hormone,luteinizing hormone/follicle stimulating hormone,and estradiol in the observation group were significantly lower than those in the control group,and the difference was statistically significant(P<0.05).The fasting insulin,fasting blood glucose,and insulin resistance index in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).The ovulation rate and pregnancy rate in the observation group were significantly higher than those in the control group,and the difference was statistically significant(P<0.05).The abortion rate in the observation group was significantly lower than that in the control group,and the difference was not statistically significant(P>0.05).The incidence of complications in the observation group was significantly higher than that in the control group(16.67%vs 13.33%),and the difference was not statistically significant(P>0.05).Conclusion Combined cyclic therapy of estrogen and progesterone and metformin can effectively improve the symptoms of patients with polycystic ovary syndrome and type 2 diabetes.It can improve the patient's pregnancy rate and ovulation rate.and the medication is safe.
作者
黄红英
HUANG Hongying(Department of Obstetrics and Gynecology,Heze Mudan People's Hospital,Heze,Shandong Province,274000 China)
出处
《糖尿病新世界》
2023年第16期98-101,共4页
Diabetes New World Magazine
关键词
多囊卵巢综合征
2型糖尿病
合并症
雌激素
孕激素
周期疗法
二甲双胍
Polycystic ovary syndrome
Type 2 diabetes mellitus
Complications
Estrogen
Progesterone
Cycle therapy
Metformin
