摘要
目的 分析成都市新都区人民医院分离的铜绿假单胞菌临床分布和耐药性特征,为临床抗感染治疗提供参考依据。方法 收集2020年1月至2021年12月间,成都市新都区人民医院各科室住院患者标本中分离出的不重复铜绿假单胞菌的菌株,采用WalkAway-40PLUS全自动微生物鉴定及药敏分析系统进行菌株鉴定和药敏试验,并进行统计学分析。结果 共分离出396株铜绿假单胞菌的非重复菌株,主要来源于痰标本(76.52%,303株),其次是脓液(5.30%,21株)、分泌物(3.54%,14株);科室分布以呼吸内科最高(39.90%),其次为儿科/新生儿科(13.13%)和重症医学科(10.10%)。铜绿假单胞菌对头孢哌酮/舒巴坦的耐药率最高(21.06%),妥布霉素的耐药率最低(1.33%)。结论 铜绿假单胞菌的耐药率正呈现一种上升趋势,应引起高度重视,可合理选择抗菌药物,联合用药,减少耐药菌株的产生。
Objective To analyze the serotype distribution and drug resistance of Pseudomonas aeruginosa(P.aeruginosa)in Xindu District People′s Hospital of Chengdu,and to provide a reference for clinical anti-infection treatment.Methods The isolated P.aeruginosa from inpatient specimens from all departments of Xindu District People′s Hospital of Chengdu between January 2020 and December 2021 were collected.Strain identification and drug susceptibility tests were performed on WalkAway-40PLUS.Results A total of 396 non-repetitive strains of P.aeruginosa were isolated,among which 303 strains were from sputum specimens(76.52%),followed by 21 strains from pus(5.30%)and 14 strains from secretion(3.54%).The detection rate was the highest in respiratory department(39.90%),followed by pediatrics department(13.13%)and ICU(10.10%).The resistance rate of P.aeruginosa to cefoperazone/sulbactam was the highest(21.06%),and the lowest to tobramycin(1.33%).Conclusion The drug resistance rate of Pseudomonas aeruginosa is on the rise in the past two years.Rational selection of antibiotics and combination of drugs can reduce the production of drug-resistant strains.
作者
刘小花
朱腾
陈涛
黄华翠
陈宇宁
LIU Xiao-hua;ZHU Teng;CHEN Tao;HUANG Hua-cui;CHEN Yu-ning(Department of Medical Laboratory,Xindu District People′s Hospital of Chengdu,Chengdu 610500,Sichuan,China)
出处
《广东医学》
CAS
2023年第8期1014-1017,共4页
Guangdong Medical Journal
基金
四川省医学(青年创新)科研课题计划(Q19050)。
关键词
铜绿假单胞菌
临床分布
耐药性
Pseudomonas aeruginosa
clinical distribution
drug resistance
