摘要
The Chouchani lab recently reported in Nature that a dynamic intracellular lactate is a physiological regulator for cell cycle progress.They also showed that accumulated lactate in cell mitosis directly binds and inhibits Sentrin/SUMO-specific pro-tease 1 to enrich SUMO2/3-modification of anaphase-promot-ing complex 4(APC4),which promotes the degradation of APC/C complexes,leading to mitosis exit.
