摘要
目的 探索血清组蛋白脱乙酰化酶1(HDAC1)和骨形态发生蛋白7(BMP7)对冠心病患者冠状动脉介入术(PCI)术后发生不良心血管事件的预测价值。方法 纳入2020年1月至2022年1月本院接收且均进行PCI术的冠心病患者90例为实验组。根据冠心病患者PCI术后6个月内心血管不良事件(MACE)发生情况进一步将其分为MACE组(28例)和非MACE组(62例)。选取同期健康体检者80例为对照组。采用酶联免疫吸附(ELISA)法检测血清HDAC1、BMP7水平;采用多因素Logistic回归分析MACE事件结局的影响因素;采用受试者工作曲线(ROC)来评价血清HDAC1、BMP7在冠心病预测中的临床意义。结果 相较于对照组,实验组患者血清HDAC1水平显著升高,BMP7水平显著降低,且差异具有统计学意义(P<0.05)。与对照组相比,非MACE和MACE组患者血清TC、LDL-C显著升高,且差异具有统计学意义(P<0.05);相较于非MACE组,MACE组患者血清HDAC1、TC、LDL-C水平显著升高,BMP7水平显著降低,且差异具有统计学意义(P<0.05)。多因素Logistic回归分析发现,TC、LDL-C、高水平HDAC1均是冠心病患者PCI术后发生不良心血管事件的独立危险因素(P<0.05),高水平BMP7是冠心病患者PCI术后发生不良心血管事件的独立保护因素(P<0.05)。ROC结果显示,血清HDAC1、BMP7水平及二者联合预测冠心病患者PCI术后不良心血管事件的AUC分别为0.773、0.724、0.840,其中联合预测AUC显著高于二者单独预测AUC(Z=4.976、3.597,P<0.05)。结论 冠心病患者PCI术后患者血清HDAC1水平升高、BMP7水平降低,与不良心血管事件关系密切,高水平HDAC1是不良心血管事件的独立危险因素,高水平BMP7是不良心血管事件的独立保护因素,均有望成为PCI术后发生不良心血管事件的预测因子。
Objective To explore the predictive value of serum deacetylase 1(HDAC1)and bone morphogenetic protein 7(BMP7)for adverse cardiovascular events after coronary intervention(PCI)in patients with coronary heart disease.Methods During January 2020 to January 2022,90 patients with coronary heart disease who underwent PCI surgery were included as the experimental group.According to the occurrence of adverse cardiovascular events(MACE)within 6 months after PCI surgery,patients with coronary heart disease were further divided into MACE group(28 cases)and non-MACE group(62 cases).In addition,a total of 80 healthy patients were selected as the control group.Serum HDAC1 and BMP7 levels were detected by enzyme-linked immunosorbent(ELISA).Multivariate logistic regression was used to analyze the influencing factors of MACE event outcomes.The receiver working curve(ROC)was drawn to evaluate the clinical significance of serum HDAC1 and BMP7 in coronary heart disease.Results Compared with the control group,the serum HDAC1 level in the experimental group was significantly higher,while the serum BMP7 level was significantly lower(P<0.05).Compared with the control group,serum TC and LDL-C were significantly increased in the non-MACE and MACE groups(P<0.05);Compared with the non-MACE group,serum HDAC1,TC,LDL-C levels in the MACE group were significantly higher,while the BMP7 level was significantly lower(P<0.05).Multivariate logistic regression analysis showed that TC,LDL-C and high HDAC1 were independent risk factors for adverse cardiovascular events in patients with coronary heart disease after PCI(P<0.05),and high level of BMP7 was an independent protective factor for adverse cardiovascular events in patients with coronary heart disease after PCI(P<0.05).ROC curve showed that AUCs of serum HDAC1,BMP7 levels and their combined prediction of adverse cardiovascular events in patients with coronary heart disease after PCI were 0.773,0.724 and 0.840,respectively.The combined prediction of AUC was significantly higher than that of the individual marker(Z=4.976,3.597,P<0.05).Conclusion The serum HDAC1 level increases and BMP7 level decreases in patients with coronary heart disease after PCI,which is closely related to adverse cardiovascular events.High HDAC1 is an independent risk factor for adverse cardiovascular events,while high level of BMP7 is an independent protective factor for adverse cardiovascular events,and they are expected to become clinical predictors of adverse cardiovascular events after PCI.
作者
龚倩
黎东
李郁
罗彩东
GONG Qian;LI Dong;LI Yu;LUO Caidong(Department of Cardiovascular Medicine,Mianyang Central Hospital,Mianyang 621099,China)
出处
《标记免疫分析与临床》
CAS
2023年第9期1509-1514,共6页
Labeled Immunoassays and Clinical Medicine
基金
2018年四川省卫生和计划生育委员会科研课题项目(编号:18ZD007)。
关键词
冠心病
经皮冠状动脉介入术
去乙酰化酶1
骨形态发生蛋白7
不良心血管事件
Coronary heart disease
Percutaneous coronary intervention
Deacetylase 1
Bone morphogenetic protein 7
Adverse cardiovascular events
