摘要
目的比较氟米龙滴眼液、妥布霉素地塞米松滴眼液在翼状胬肉患者术后的应用效果,为临床选择提供参考。方法随机数字表法将2020年4月至2021年4月上海市东方医院吉安医院眼科收治的90例(90眼)翼状胬肉患者分为对照组和研究组,每组45例(45眼),对照组患者术后给予氟米龙滴眼液干预,研究组患者术后给予妥布霉素地塞米松滴眼液干预,比较两组患者术后复发率、眼表疾病指数(ocular surface disease index,OSDI)评分、角膜愈合时间、泪膜破裂时间(tear film breakup time,TBUT)、泪液分泌试验(schirmerⅠtest,SⅠt)及不良反应发生率。结果两组患者术后复发率比较差异无统计学意义(P>0.05);两组患者术后1个月、3个月的OSDI评分均低于本组术前(P<0.05),两组组间比较,差异无统计学意义(P>0.05);研究组患者的角膜愈合时间短于对照组(P<0.05);两组患者术后1个月、3个月的TBUT、SⅠt均高于本组术前(P<0.05),两组组间比较,差异无统计学意义(P>0.05);研究组患者术后不良反应的发生率明显低于对照组(P<0.05)。结论氟米龙滴眼液和妥布霉素地塞米松滴眼液均能有效改善患者的眼部基本状况,对翼状胬肉复发的控制效果相当,但妥布霉素地塞米松滴眼液能缩短患者术后角膜愈合的时间,不良反应更少。
Objective To compare the application effect of flumetholone eye drops and tobramycin dexamethasone eye drops in patients with pterygium after operation,so as to provide reference for clinical selection.Methods A total of 90 cases(90 eyes)of pterygium patients admitted to the Department of Ophthalmology of Ji'an Hospital,Shanghai Oriental Hospital from April 2020 to April 2021 were divided into control group and research group,45 cases(45 eyes)in each group.The patients in control group were given flumetholone eye drops after surgery,and the patients in research group were treated with tobramycin dexamethasone eye drops after surgery.The postoperative recurrence rate,ocular surface disease index(OSDI)score,corneal healing time,tear film breakup time(TBUT),schirmerⅠtest(SⅠt)and incidence of adverse reactions.Results There was no significant difference in the postoperative recurrence rate between two groups(P>0.05).The OSDI scores of the two groups at 1 month and 3 months after the operation were lower than those before the operation in the same group(P<0.05).There was no significant difference between the two groups(P>0.05);The corneal healing time of research group was shorter than that of control group(P<0.05);The TBUT and SⅠt of the two groups at 1 month and 3 months after surgery were significantly higher than before operation in the same group(P<0.05),there was no significant difference between the two groups(P>0.05);the incidence of postoperative adverse reactions in research group was significantly lower than that in control group(P<0.05).Conclusion Flumiolone eye drops and tobramycin dexamethasone eye drops can effectively improve the basic eye condition of patients,and have similar control effects on pterygium recurrence.However,tobramycin dexamethasone eye drops can shorten the time for postoperative corneal healing in patients,with fewer adverse reactions,and are worth promoting and using.
作者
郭清
张巧
刘海芳
GUO Qing;ZHANG Qiao;LIU Haifang(Department of Ophthalmology,Ji’an Hospital,Shanghai Oriental Hospital,Ji’an 343000,Jiangxi,China)
出处
《中国现代医生》
2023年第30期60-63,共4页
China Modern Doctor
基金
江西省吉安市科技计划项目([2019]8号(75))。
关键词
翼状胬肉
氟米龙滴眼液
妥布霉素地塞米松滴眼液
复发
Pterygium
Fluorometholone eye drops
Tobramycin and dexamethasone eye drops
Recurrence
