摘要
巨噬细胞是组织防御前线的哨兵,是机体对抗入侵病原体的重要武器,其代谢方式和功能与疾病的发展转归密切相关。通常,巨噬细胞优先选择葡萄糖氧化磷酸化(OXPHOS)途径代谢产能,在缺氧环境下则以糖酵解为主。而肿瘤巨噬细胞在氧气充足的情况下也通过糖酵解产能,这便是经典的“沃博格效应”。研究表明,M1型巨噬细胞的糖代谢重编程与肿瘤细胞类似,表现为以有氧糖酵解为主和OXPHOS为辅,而M2型则恰好相反,因此阻断糖代谢重编程可有效抑制炎症反应。本文重点阐述了巨噬细胞在炎症疾病调控中的关键作用及其糖代谢重编程的可能机制。以期为免疫和代谢性相关疾病的防治提供新策略。
Macrophages are sentinels on the front line of tissue defense and an important weapon for the body to fight against invading pathogens.Their metabolic patterns and functions are closely related to the development and outcome of diseases.In general,macrophages preferentially select the oxidative phosphorylation of glucose(OXPHOS)pathway to metabolize energy production,and in hypoxic environments,glycolysis is the predominant.However,tumor macrophages can also produce energy through glycolysis in the presence of sufficient oxygen,which is the classic"Warburg effect".Studies have shown that the reprogramming of glucose metabolism in M1 type macrophages is similar to that of tumor cells,showing that aerobic glycolysis is dominant and OXPHOS is supplemented,while M2 type macrophages are just the opposite,so blocking glucose metabolism reprogramming can effectively inhibit inflammation reaction.This review focuses on the key role of macrophages in the regulation of inflammatory diseases and the possible mechanism of there programming of glucose metabolism,in order to provide new strategies for the prevention and treatment of immune and metabolic related diseases.
作者
陈娟
周永学
闫曙光
李京涛
魏海梁
王文霸
CHEN Juan;ZHOU Yongxue;YAN Shuguang;LI Jingtao;WEI Hailiang;WANG Wenba(Shaanxi University of Chinese Medicine,Xianyang 712046,China)
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2023年第10期2098-2103,共6页
Chinese Journal of Immunology
基金
国家自然科学基金项目(81873233)
陕西中医药大学学科创新团队建设项目(2019-YL05)。
关键词
巨噬细胞
重编程
糖酵解
氧化磷酸化
Macrophages
Reprogramming
Glycolysis
Oxidative phosphorylation
