摘要
胆道肿瘤是一类起源于胆道上皮细胞、隐匿性强、侵袭性高的消化道恶性肿瘤,死亡率高。早期发现和诊断被认为是获得根治性手术治疗的关键,R0切除是胆道肿瘤患者获益的有效措施,但大多数患者表现为局部进展或者已伴有远处转移,无法进行根治性手术治疗。采用现有的诊疗方法,患者的5年生存率依然很低。因此,如何提高胆道肿瘤的诊疗水平、延长生存期、提高患者的生活质量,已成为当前迫切需要解决的问题。针对胆道肿瘤的特性,以及临床病理分子学研究的不断深入,当前辅助治疗、精准靶向治疗、免疫治疗以及综合治疗被认为是手术以外的标准化诊疗模式和研究方向。因此,本文就当前国内外胆道肿瘤的研究新进展作一系统性分析,旨在为诊治胆道肿瘤患者提供策略。
Biliary tract cancers(BTC)is a type of digestive tract malignant tumors that originate from biliary epithelial cells,is characterized by strong occult and highly invasive,and has a high mortality rate.Early detection and diagnosis are considered to be the key to obtaining radical surgical treatment.R0 resection is an effective measure to benefit patients with BTC.However,most of the patients present with local progression or associated distant metastasis,making it impossible to undergo radical surgical treatment.With existing diagnosis and treatment methods,the 5-year survival rate of patients is still very low.Therefore,how to improve the level of diagnosis and treatment of BTC,prolong survival,and improve the quality of life has become an urgent problem to be solved.In view of the characteristics of BTC and the continuous deepening of clinical pathological molecular research,adjuvant therapy,precisely targeted therapy,immunotherapy,and comprehensive treatment are currently considered to be standardized diagnosis and treatment models and research directions beyond surgery.Therefore,this article systematically analyzes the current research progress of BTC both domestically and internationally,aiming to provide strategies for the diagnosis and treatment of patients with BTC.
作者
陈超波
毛谅
仇毓东
Chen Chaobo;Mao Liang;Qiu Yudong(Department of General Surgery,Xishan People′s Hospital of Wuxi City,Wuxi 214105,China;Department of General Surgery,the Affiliated Drum Tower Hospital of Nanjing University Medical School,Nanjing 210008,China)
出处
《国际外科学杂志》
2023年第8期545-551,共7页
International Journal of Surgery
基金
国家自然科学基金(31971518)
江苏省卫健委重点项目(ZD2021017)
无锡市卫健委面上项目(M202160)。
关键词
胆道肿瘤
外科手术
诊断
辅助治疗
免疫治疗
综合治疗
Biliary tract neoplasms
Surgical procedures,operative
Diagnosis
Adjuvant therapy
Immunotherapy
Comprehensive treatment
