摘要
目的:探讨泼尼松龙联合利培酮治疗退化型孤独症谱系障碍(ASD)患儿的效果。方法:选取2022年8月—2023年2月北京航天总医院儿科收治的90例退化型ASD患儿。根据信封随机法将其分为试验组与对照组,各45例。对照组给予利培酮治疗,试验组给予泼尼松龙联合利培酮治疗。比较两组临床疗效,治疗前后行为症状、治疗情况及病情严重程度、炎症因子。结果:试验组治疗后的总有效率为95.56%,高于对照组的82.22%,差异有统计学意义(P<0.05)。治疗后,两组交往、感觉、生活自理和语言评分均降低,试验组交往、感觉、生活自理和语言评分均低于对照组,差异有统计学意义(P<0.05)。治疗后,两组孤独症治疗评定量表(ATEC)、儿童孤独症评定量表(CARS)评分均降低,试验组ATEC、CARS评分均低于对照组,差异有统计学意义(P<0.05)。治疗后,两组白细胞介素-1(IL-1)、γ干扰素(IFN-γ),白细胞介素-8(IL-8)水平均下降,试验组IL-1、IFN-γ、IL-8水平均低于对照组,差异有统计学意义(P<0.05)。结论:在退化型ASD患儿治疗中,泼尼松龙联合利培酮治疗效果显著,有助于降低炎症因子水平,促进孤独症症状改善。
Objective:To explore the effect of Prednisolone combined with Risperidone in the treatment of children with degenerative autism spectrum disorder(ASD).Method:A total of 90 children with degenerative ASD treated in the Department of Pediatrics of Beijing Aerospace General Hospital from August 2022 to February 2023 were selected.According to envelope random method,they were divided into experimental group and control group,45 cases in each group.The control group was treated with Risperidone,and the experimental group was treated with Prednisolone combined with Risperidone.The clinical efficacy,behavioral symptoms,treatment status and severity of the condition,and inflammatory factors before and after treatment were compared between the two groups.Result:After treatment,the total effective rate of the experimental group was 95.56%,which was higher than 82.22%of the control group,and the difference was statistically significant(P<0.05).After treatment,the scores of communication,sensation,life self-care and language were decreased in both groups,and the scores of communication,sensation,life self-care and language in experimental group were lower than those in control group,and the differences were statistically significant(P<0.05).After treatment,the scores of autism treatment evaluation checklist(ATEC)and childhood autism rating scale(CARS)were decreased in both groups,and the scores of ATEC and CARS in experimental group were lower than those in control group,and the differences were statistically significant(P<0.05).After treatment,the levels of interleukin-1(IL-1),interferon-γ(IFN-γ)and interleukin-8(IL-8)in both groups were decreased,and the levels of IL-1,IFN-γand IL-8 in experimental groups were lower than those in control group,and the differences were statistically significant(P<0.05).Conclusion:In the treatment of children with degenerative ASD,Prednisolone combined with Risperidone has a significant treatment effect,helping to reduce the level of inflammatory factors and promote the improvement of autism symptoms.
作者
许力飞
XU Lifei(Beijing Aerospace General Hospital,Beijing 100076,China)
出处
《中外医学研究》
2023年第28期149-153,共5页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
泼尼松龙
退化型孤独症谱系障碍
炎症因子
利培酮
儿童
Prednisolone
Degenerative autism spectrum disorder
Inflammatory factors
Risperidone
Children
