摘要
目的 早产儿蜡样芽孢杆菌败血症病例报告,为临床提供参考。方法 分析枣庄市妇幼保健院2019年7月11日(病例1)、2022年6月17日(病例2)收治的2例发生蜡样芽孢杆菌败血症的早产儿,其中病例1发生经外周静脉穿刺中心静脉置管(PICC)相关的血流感染、败血症、休克、化脓性脑膜炎,病例2为败血症;分析对比两个病例的置管、临床表现、感染后实验室检查[包括血常规、C-反应蛋白(CRP)、降钙素原(PCT)、脑脊液常规、血培养等]。结果 与病例2相比,病例1感染蔓延迅速、病情变化快、全身症状重,其血常规、CRP、PCT、脑脊液、血气均迅速提示异常。结论 中心静脉置管引起的早产儿蜡样芽孢杆菌败血症,感染进展更迅速,全身症状显著,有效抗菌药物治疗也难挽回死亡结局。
OBJECTIVE To analyze case reports of Bacillus cereus sepsis in preterm neonates,and to provide reference for clinical practice.METHODS Two cases of preterm neonates who developed Bacillus cereus sepsis admitted to Zaozhuang Maternal and Child Health Hospital on Jul.11,2019(case 1)and Jun.17,2022(case 2)were analyzed,in which case 1 developed bloodstream infection,sepsis,shock,and purulent meningitis associated with peripheral venous interposition of central venous cannulae(PICCs)via peripheral vein puncure,and case two developed sepsis.The catheterization,clinical manifestations,and post-infection laboratory tests(including blood routine,CRP,PCT,cerebrospinal fluid routine,blood culture,etc)of the two cases were analyzed and compared.RESULTS Compared with case 2,case 1 showed a rapid spread of infection,rapid changes in the condition,and severe systemic symptoms,with rapid abnormalities in blood routine,CRP,PCT,cerebrospinal fluid,and blood gas.CONCLUSION Bacillus cereus sepsis in preterm neonates caused by central venous catheterization was associated with a more rapid progression of infection and significant systemic symptoms,and effective antibiotic treatment was difficult to salvage the death outcome.
作者
李晓晓
张明月
杨恩荣
杨旻
LI Xiao-xiao;ZHANG Ming-yue;YANG En-rong;YANG Min(Zaozhuang Maternal and Child Health Hospital,Zaozhuang,Shandong 277000,China)
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2023年第20期3166-3169,共4页
Chinese Journal of Nosocomiology
基金
上海市科技创新行动计划医学创新研究专项基金资助项目(21Y21900802)。
关键词
蜡样芽胞杆菌
早产儿
败血症
导管相关血流感染
Bacillus cereus
Premature infants
Sepsis
Catheter-related bloodstream infection
