摘要
目的探讨孕妇血清E-选择素(E-selection)、富亮氨酸重复序列相互作用蛋白(leucine-rich repeat containing protein,LRRFIP)、同型半胱氨酸(homocysteine,Hcy)水平与妊娠期高血压的相关性。方法选取漳州市妇幼保健院门诊2019年6月—2020年10月收治的80例妊娠期高血压孕妇为观察组,同期80名正常妊娠孕妇为对照组,根据妊娠结局将妊娠期高血压患者分为不良妊娠(26例)和良好妊娠(54例)两个亚组。比较两组临床资料、入院时血清E-selection、LRRFIP、Hcy水平,比较不同妊娠结局患者入院时血清E-selection、LRRFIP、Hcy水平,分析入院时血清E-selection、LRRFIP、Hcy水平与临床资料、妊娠期高血压发生及不良妊娠结局的相关性,受试者工作特征曲线(receiver operating characteristic,ROC)分析入院时血清E-selection、LRRFIP、Hcy水平联合检测对妊娠期高血压患者不良妊娠结局的预测价值。结果观察组收缩压(systolic blood pressure,SBP)、舒张压(diastolic blood pressure,DBP)高于对照组(P<0.05);入院时,观察组血清E-selection、LRRFIP、Hcy水平高于对照组(P<0.05);入院时,不良妊娠结局患者血清E-selection、LRRFIP、Hcy水平高于良好妊娠结局患者(P<0.05);入院时,血清E-selection、LRRFIP、Hcy水平与SBP、DBP、妊娠期高血压、不良妊娠结局呈正相关(P<0.05);入院时血清E-selection、LRRFIP、Hcy水平联合预测妊娠期高血压患者发生不良妊娠结局的AUC为0.786,最佳敏感度、特异度分别为92.31%、64.81%。结论妊娠期高血压患者血清E-selection、LRRFIP、Hcy水平呈异常表达,并与妊娠结局具有密切联系。
Objective To investigate the relationship between serum E-selection,leucine-rich repeat interacting protein(LRRFIP),homocysteine(Hcy)levels and gestational hypertension.Methods A total of 80 cases of hypertensive pregnancy in outpatient service,Zhangzhou Maternal and Child Care Hospital from June 2019 to October 2020 were selected as the observation group,and 80 cases of normal pregnant women in the same period were selected as the control group.According to the pregnancy outcome,the patients with hypertensive pregnancy were divided into two subgroups,adverse pregnancy(26 cases)and good pregnancy(54 cases).The clinical data,serum E-selection,LRRFIP and Hcy levels at admission were compared between the two groups,and the serum E-selection,LRRFIP and Hcy levels at admission were compared in patients with different pregnancy outcomes.The correlation between serum E-selection,LRRFIP and Hcy levels at admission and clinical data,gestational hypertension and adverse pregnancy outcomes was analyzed.The predictive value of serum E-selection,LRRFIP and Hcy levels at admission for adverse pregnancy outcomes in patients with gestational hypertension was analyzed by receiver operating characteristic(ROC)analysis.Results Systolic blood pressure(SBP),diastolic blood pressure(DBP)in the observation group were higher than those in the control group(P<0.05).The levels of serum E-selection,LRRFIP and Hcy in the observation group were higher than those in the control group(P<0.05).At admission,the levels of serum E-selection,LRRFIP and Hcy in patients with poor pregnancy outcome were higher than those in patients with good pregnancy outcome(P<0.05).Serum E-selection,LRRFIP and Hcy levels at admission were positively correlated with SBP,DBP,gestational hypertension and adverse pregnancy outcome(P<0.05).The AUC of serum E-selection,LRRFIP and Hcy levels at admission for predicting adverse pregnancy outcome in patients with pregnancy-induced hypertension was 0.786,with the best sensitivity and specificity of 92.31%and 64.81%respectively.Conclusion The levels of serum E-selection,LRRFIP and Hcy are abnormal in patients with pregnancy-induced hypertension,which are closely related to pregnancy outcome.
作者
陈美玲
魏伟龙
CHEN Meiling;WEI Weilong(Department of Laboratory,Zhangzhou Maternal and Child Care Hospital,Zhangzhou Fujian 363000,China;Department of Obstetrics and Gynecology,the Third Hospital of Zhangzhou,Zhangzhou Fujian 363000,China)
出处
《中国卫生标准管理》
2023年第20期10-14,共5页
China Health Standard Management
