摘要
肺癌是慢性阻塞性肺疾病(COPD)患者最常见的合并症之一,合并肺癌的COPD患者往往预后更差,故在预防及治疗COPD时应对肺癌发病的危险因素进行控制。既往研究中发现,COPD患者合并肺癌的危险因素可能包括:吸烟、过低或过高的BMI、空气污染、炎症反应与易感基因。应用吸入性糖皮质激素治疗COPD可能降低合并肺癌的发病率。本文旨在回顾COPD患者并发肺癌的危险因素研究进展,并为后续研究提供新思路。
One of the most common comorbidities of chronic obstructive pulmonary disease(COPD)is lung cancer,and COPD patients with lung cancer often have a worse prognosis.Therefore,the risk factors of lung cancer should be controlled in the prevention and treatment of COPD.Various risk factors for lung cancer in COPD patients have been discovered in previous studies,including smoking,low or high body mass index,air pollution,inflammation,and susceptibility genes.The use of inhaled corticosteroids in the treatment of COPD may reduce the incidence of lung cancer.This article reviews the research progress of the risk factors of COPD complicated with lung cancer,which may provide new ideas for subsequent research.
作者
李信麟
宋祝
LI Xin-lin;SONG Zhu(Peking University Health Science Center,Beijing 100191,China;Department of Respiratory and Critical Care Medicine,Peking University Third Hospital,Beijing 100191,China)
出处
《内科急危重症杂志》
2023年第5期358-362,共5页
Journal of Critical Care In Internal Medicine
基金
北京大学第三医院院队列项目(No:BYSYDL2021013)。
关键词
慢性阻塞性肺疾病
肺癌
危险因素
研究现状
Chronic obstructive pulmonary disease
Lung cancer
Risk factors
Research status
