摘要
目的探讨清宣止咳颗粒联合盐酸多西环素片治疗儿童支原体肺炎的临床疗效。方法选取2020年8月—2023年3月张家口市妇幼保健院收治的116例肺炎支原体肺炎患儿,根据随机数字表法将116例患儿分为对照组和治疗组,每组各58例。对照组口服盐酸多西环素片,2.2 mg/kg,1次/d。治疗组在对照组基础上温水冲服清宣止咳颗粒,3次/d,2~3岁:0.5袋/次,4~6岁:0.75袋/次,7岁及以上:1袋/次。两组患儿连续治疗7 d。观察两组的临床疗效,比较两组的患儿症状体征的消失时间、用力肺活量(FVC)、呼气峰值流速(PEF)、最大呼气中期流量(MMEF)、C反应蛋白(CRP)、血沉(ESR)、乳酸脱氢酶(LDH)、降钙素(CT)。结果治疗后,治疗组的总有效率为94.83%,明显高于对照组的总有效率82.76%,组间差异显著(P<0.05)。治疗后,治疗组患儿的咳嗽消失时间、肺部啰音消失时间、肺部炎症完全吸收时间均明显短于对照组(P<0.05)。治疗后,治疗组的FVC、PEF、MMEF高于治疗前(P<0.05),且治疗组的FVC、PEF、MMEF高于对照组(P<0.05)。治疗后,两组的血清CRP、ESR、LDH、CT水平显著降低(P<0.05),且治疗组的血清CRP、ESR、LDH、CT水平明显低于对照组(P<0.05)。结论宣止咳颗粒联合盐酸多西环素片治疗儿童支原体肺炎的疗效良好,可改善临床症状和肺通气功能,显著减轻炎症反应。
Objective To investigate the clinical effect of Qingxuan Zhike Granules combined with Doxycycline Hyclate Tablets in treatment of mycoplasma pneumonia in children.Methods Children(116 cases)with mycoplasma pneumonia in Zhangjiakou Maternal and Child Health Hospital from August 2020 to March 2023 were divided into control and treatment groups according to the random number table method,and each group had 58 cases.Children in the control group were po administered with Doxycycline Hyclate Tablets,2.2 mg/kg,once daily.Children in the treatment group were po administered with Qingxuan Zhike Granules on the basis of the control group,three times daily,2—3 years old:0.5 bags/time,4—6 years old:0.75/time,and 7 years old and above:1 bag/time.Children in two groups were treated for 7 d.After treatment,the clinical efficacies were evaluated,and the disappearance times of symptoms and signs,FVC,PEF,MMFF,CRP,ESR,LDH,and CT in two groups were compared.Results After treatment,the total effective rate of 94.83%in the treatment group was significantly higher than 82.76%in the control group,with significant differences between groups(P<0.05).After treatment,the cough disappearance time,lung rale disappearance time,and complete absorption time of lung inflammation in the treatment group were significantly shorter than those in the control group(P<0.05).After treatment,FVC,PEF,and MMEF of the treatment group were higher than before treatment(P<0.05),and FVC,PEF,and MMEF of the treatment group were higher than those of the control group(P<0.05).After treatment,the levels of CRP,ESR,LDH,and CT in two groups were significantly decreased(P<0.05),and the levels of CRP,ESR,LDH and CT in the treatment group were lower than those in the control group(P<0.05).Conclusion Qingxuan Zhike Granules combined with Doxycycline Hyclate Tablets have good efficacy in treatment of mycoplasma pneumonia in children,which can improve clinical symptoms and pulmonary ventilation function,significantly reduce inflammatory reactions.
作者
冯长洁
张晓俞
白建强
李婷婷
FENG Chang-jie;ZHANG Xiao-yu;BAI Jian-qiang;LI Ting-ting(Fifth Department of Pediatrics,Zhangjiakou Maternal and Child Health Hospital,Zhangjiakou 075000,China;Third Department of Pediatrics,Zhangjiakou Maternal and Child Health Hospital,Zhangjiakou 075000,China)
出处
《现代药物与临床》
CAS
2023年第10期2495-2499,共5页
Drugs & Clinic
基金
张家口市重点研发计划项目(2221200D)。
