摘要
目的:探讨高龄老人骨转换标志物与肾功能的相关性。方法:采用横断面研究设计,选取2015至2021年在某院健康体检的474例高龄老人,根据肾小球滤过率分为肾功能正常组和肾功能异常组。采用JASP 16.0.0软件进行统计分析,多因素Logistic回归分析骨转换代谢标志物与肾功能的相关性。结果:474例老年人平均年龄为(78.52±3.17)岁,男性患者占比61.8%,男性肾功能受损率显著低于女性肾功能受损率(37.4%比62.6%,P<0.001)。校正年龄、性别、身体质量指数、舒张压、总胆固醇、空腹血糖、同型半胱氨酸、25-羟维生素D3、Ⅰ型前胶原氨基端前肽(PINP)、β胶原降解产物(β-CTX)、全段甲状旁腺激素和骨钙素等因素后,多因素Logistic回归分析结果显示,25-羟维生素D3水平与肾功能受损患病率呈负相关(P<0.05)。与β-CTX≤0.36 pg/ml组相比,β-CTX>0.37 pg/ml组的肾功能受损患病率增加(P<0.05),而高尿酸血症患病率则降低(P<0.05)。在女性患者中,25-羟维生素D3下降和β-CTX升高与肾功能受损显著相关(P<0.05)。结论:较高水平的β-CTX和较低水平的25-羟维生素D3与高龄老人肾功能下降有关。
Objective To explore the relationship between markers of bone turnover metabolism and renal function in the elderly people.Methods A cross-sectional study design was conducted,and 474 elderly individuals who underwent health examinations at the hospital from 2015 to 2021 were selected.Based on their glomerular filtration rates,the subjects were divided into the normal renal function group and the abnormal renal function group.Statistical analysis was conducted with the JASP 16.0.0 software,and multivariate logistic regression analysis was conducted to investigate the relationship between bone turnover metabolic markers and renal function.Results The average age of the 474 elderly people was 78.52±3.17 years old,with a male population accounting for 61.8%.The renal dysfunction rate in the male was significantly lower than that in the female 37.4%vs 62.6%,(P<0.001).After adjusting for age,gender,body mass index,diastolic blood pressure,total cholesterol,fasting blood glucose,homocysteine,25-hydroxyvitamin D3,procollagen type 1 amino-terminal propeptide(PINP),β-cross-linked C-telopeptide of type I collagen(β-CTX),intact parathyroid hormone,and osteocalcin,the results of multivariate logistic regression analysis showed that higher level of 25-hydroxyvitamin D3(P<0.05)were associated with a lower incidence of renal dysfunction in the elderly people.Compared to the group with β-CTX≤0.36 pg/ml,the group with β-CTX>0.37 pg/ml showed a higher incidence of renal dysfunction(P<0.05)and a lower incidence of hyperuricemia(P<0.05).In the female population,25-hydroxyvitamin D3 decrease and β-CTX increase were correlated with the renal dysfunction(P<0.05).Conclusion Higher level of β-CTX and lower level of 25-hydroxyvitamin D3 were associated with the decreased renal function in the elderly people.
作者
潘春江
李科
李新楼
杨博
任雪玲
Pan Chunjiang;Li Ke;Li Xinlou;Yang Bo;Ren Xueling(Department of Medical Research,Chinese PLA Strategic Support Force Medical Center,Beijing 100101;Department of Respiratory and Critical Care Medicine,Second Medical Center of Chinese PLA General Hospital,Beijing 100853,China)
出处
《中华肾病研究电子杂志》
2023年第5期260-264,共5页
Chinese Journal of Kidney Disease Investigation（Electronic Edition）
关键词
骨转换代谢
肾功能
高龄
相关性
Bone turnover metabolism
Renal function
Elderly
Correlation
