摘要
人们通常认为抗生素的选择压力是造成抗生素抗性基因快速扩散的原因,但是越来越多的研究表明环境中非抗生素类新污染物也能够造成抗生素抗性基因快速扩散。本文对非抗生素类新污染物影响质粒携带抗性基因水平转移规律和机制研究进展进行了归纳总结。目前的研究大多集中在内分泌干扰物、药品及个人护理产品以及纳米材料影响R质粒携带抗生素抗性基因水平转移,相关机制主要关注非抗生素类新污染物对活性氧、应激反应以及细胞膜通透性的影响。持久性有机污染物影响质粒携带抗性基因水平转移规律以及非抗生素类新污染物对其他质粒携带的抗生素抗性基因水平转移规律和其他类型的机制可以作为未来的研究方向。
It is generally believed that the pressure of antibiotic selection is the cause of rapid spread of antibiotic resistance genes(ARGs),but more and more evidences have shown that non-antibiotic emerging contaminants in the environment are also the cause of rapid spread of ARGs.In this paper,the research progress on the rule and mechanism of non-antibiotic emerging contaminants affecting the horizontal transfer of antibiotic resistance genes mediated by plasmids was summarized.At present,most of the researches focus on the laws and mechanisms of endocrine disruptors,drugs and personal care products and nanomaterials affecting the horizontal transfer of ARGs mediated by R plasmid.The mechanisms mainly include the effects of emerging nonantibiotic contaminants on re-active oxygen species,SOS and cell membrane permeability.The horizontal gene transfer law induced by persistent organic pollutants requires attention.And more types of plasmids and transfer mechanisms should be taken as fu-ture research directions.
作者
傅欣玥
杨晓波
邱志刚
Fu Xinyue;Yang Xiaobo;Qiu Zhigang(College of Marine Ecology and Environment,Shanghai Ocean University,Shanghai 201306,China;Institute of Environmental and Operational Medicine,Academy of Military Medicine Science,Academy of Military Sciences,Tianjin 300050,China)
出处
《生态毒理学报》
CAS
CSCD
北大核心
2023年第5期1-12,共12页
Asian Journal of Ecotoxicology
基金
国家自然科学基金面上项目(42177414)。
关键词
抗生素抗性基因
水平转移
质粒
新污染物
antibiotic resistance genes
horizontal transfer
plasmid
emerging contaminants
