摘要
目的 观察中医定向透药联合抗生素治疗慢性盆腔炎的临床效果及对患者血液流变学水平的影响。方法 将66例慢性盆腔炎患者按照随机数字表法分为2组。对照组33例予抗生素治疗,治疗组33例在对照组治疗基础上加中医定向透药治疗,治疗4周后统计疗效。比较2组治疗前后血液流变学指标[血浆黏度、全血黏度(高切)、全血黏度(中切)、全血黏度(低切)、红细胞压积和红细胞聚集指数]、炎症因子[白细胞介素6(IL-6)、降钙素原(PCT)、C反应蛋白(CRP)]、免疫指标[免疫球蛋白G(IgG)、IgA及IgM]水平及健康调查简表(SF-36)评分变化。比较2组治疗期间不良反应发生情况。结果 治疗后,2组血液流变学指标血浆黏度、全血黏度(高切)、全血黏度(中切)、全血黏度(低切)、红细胞压积和红细胞聚集指数均较本组治疗前显著降低(P<0.05),且治疗组均显著低于对照组(P<0.05)。治疗后,2组炎症因子IL-6、PCT、CRP水平均较本组治疗前显著降低(P<0.05),免疫指标IgG、IgA及IgM水平均较本组治疗前升高(P<0.05),且治疗后治疗组炎症因子IL-6、PCT、CRP水平均显著低于对照组(P<0.05),免疫指标IgG、IgA及IgM水平均显著高于对照组(P<0.05)。治疗后,2组SF-36各维度评分均较本组治疗前显著升高(P<0.05),且治疗组均显著高于对照组(P<0.05)。治疗组总有效率97.0%(32/33),不良反应发生率3.03%(1/33),对照组分别为75.8%(25/33)、15.2%(5/33),治疗组总有效率高于对照组(P<0.05),不良反应发生率低于对照组(P<0.05)。结论 中医定向透药联合抗生素治疗慢性盆腔炎疗效显著,能有效改善患者血液流变学指标和临床症状,抑制炎症反应,提高机体免疫和生活质量,降低不良反应。
Objective To explore the clinical effect of traditional Chinese medicine(TCM)directional penetration therapy instrument combined with antibiotics in the treatment of chronic pelvic inflammatory disease and its influence on the level of hemorheology in patients.Methods Sixty-six patients with chronic pelvic inflammatory disease in our hospital were randomized 1∶1 to assigne into two groups.All patients were treated with antibiotics,and the patients of treatment group were addtationlly treated with TCM directional penetration therapy instrument.The therapeutic effect was calculated after 4 weeks of treatment.The blood rheology indexes(plasma viscosity,whole blood viscosity at a low shear rate,middle shear rate,and high shear rate,hematocrit and red blood cell aggregation index),inflammatory factors(Interleukin 6[IL-6],procalcitonin[PCT],C-reactive protein[CRP]),immune indicators(immunoglobulin G[IgG],IgA and IgM)and the Short Form Health Survey 36(SF-36)were included as comparisons.The treatment-emergent adverse events(TEAEs)between groups were assessed.Results After treatment,the blood rheology indexes in the both groups were significantly lower than those before treatment(P<0.05),and which in the treatment group were significantly lower than the control group(P<0.05).Significant decreased inflammatory factors(IL-6,PCT,and CRP)and significant increased immune indicators(IgG,IgA,and IgM)were detected in the both groups(all P<0.05),and the differences were significant in inflammatory factors and immune indicators between groups(all P<0.05).After treatment,the SF-36 scores in both groups were significantly increased(P<0.05),which in the treatment group was significantly higher than the control group(P<0.05).The total effective rate in the treatment group was significantly higher than that of the control group(97.0%[32/33]vs 75.8%[25/33],P<0.05).The TEAEs in the treatment group were significantly lower than those of the control group(3.03%[1/33]vs 15.2%[5/33],P<0.05).Conclusion For patients with chronic pelvic inflammatory disease,the directional penetration of TCM combined with antibiotics has a significant effect.It can effectively improve hemorrheology levels and clinical symptoms,inhibit inflammatory reactions,improve the body's immunity and quality of life,and reduce adverse reactions.
作者
高艳芳
杨娜
黄志敏
杨涛
GAO Yanfang;YANG Na;HUANG Zhimin;YANG Tao(Center for Disease Control and Prevention,Zhangjiakou Economic and Technological Development Zone,Zhangjiakou,Hebei 075000;Department of Surgery,the Number One Hospital,Zhangjiakou,Hebei 075000;Department of Obstetrics and Gynecology,the Number One Hospital,Zhangjiakou,Hebei 075000;Department of Traditional Chinese Medicine,the Number One Hospital,Zhangjiakou,Hebei 075000)
出处
《河北中医》
2023年第11期1792-1795,1801,共5页
Hebei Journal of Traditional Chinese Medicine
基金
张家口市科学技术局2022年市级科技计划自筹经费项目(编号:2221130D)。
