摘要
目的探讨超声下肺腺癌血流分级与肿瘤组织微血管密度(MVD)、血管内皮生长因子(VEGF)、缺氧诱导因子-1α(HIF-1α)表达及临床分期的关系及其意义。方法回顾性分析108例肺腺癌患者的临床资料,根据肿瘤超声下血流分级分为血流0级组(A组)、Ⅰ级组(B组)、Ⅱ级组(C组)、Ⅲ级组(D组)。对比4组患者肿瘤组织MVD值及VEGF、HIF-1α阳性表达情况,分析超声下肺腺癌血流分级与肿瘤组织MVD值及VEGF、HIF-1α表达及临床分期的相关性。结果各组肿瘤组织MVD值和VEGF、HIF-1α阳性表达比例比较差异均具有显著性(F=116.487,χ^(2)=7.143、6.982,P<0.05),B、C、D组肿瘤组织MVD值明显高于A组,C、D组明显高于B组,D组明显高于C组(P<0.05);C、D组VEGF、HIF-1α阳性表达比例均高于A组,D组高于B、C组(χ^(2)=4.589~112.502,P<0.05)。血流分级与肿瘤组织MVD值、VEGF阳性表达比例、HIF-1α阳性表达比例及临床分期均呈正相关(r=0.705~0.836,P<0.05)。结论超声下肺腺癌血流分级与肿瘤组织MVD值及VEGF、HIF-1α表达均具有相关性,且与临床分期相关,此有助于超声下对肿瘤早期及术前情况进行评估。
Objective To investigate the correlations of the blood flow grade of lung adenocarcinoma on ultrasound with microvascular density(MVD)and expression of vascular endothelial growth factor(VEGF)and hypoxia-inducible factor-1α(HIF-1α)in tumor tissue as well as clinical stage and its significance.Methods A retrospective analysis was performed on the clinical data of 108 patients with lung adenocarcinoma.The patients were divided into blood flow level 0(group A),blood flow levelⅠ(group B),blood flow levelⅡ(group C),and blood flow levelⅢ(group D)based on the blood flow level of tumor tissue on ultrasound.The four groups were compared for MVD values and positive expression of VEGF and HIF-1αin the tumor tissue;meanwhile,analyses were performed for the correlations of the blood flow grade of lung adenocarcinoma on ultrasound with MVD and expression of VEGF and HIF-1αin the tumor tissue as well as clinical stage.Results There were significant differences in MVD and positive expression rates of VEGF and HIF-1αin the tumor tissue between the groups(F=116.487,χ^(2)=7.143,6.982,P<0.05),with significantly higher MVD values in groups B,C,and D than in group A,significantly higher MVD values in groups C and D than in group B,and significantly higher MVD values in group D than in group C(P<0.05),and with significantly higher positive expression rates of VEGF and HIF-1αin groups C and D than in group A and significantly higher positive expression rates of VEGF and HIF-1αin group D than in groups B and C(χ^(2)=4.589-112.502,P<0.05).There were positive correlations of blood flow grade with MVD and positive expression rates of VEGF and HIF-1αin the tumor tissue as well as clinical stage(r=0.705-0.836,P<0.05).Conclusion There are correlations of the blood flow grade of lung adenocarcinoma on ultrasound with MVD and expression of VEGF and HIF-1αin the tumor tissue as well as clinical stage.This is useful in evaluation of early-stage tumors and preoperative conditions.
作者
雷威
李慧
LEI Wei;LI Hui(Department of Ultrasound,The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)
出处
《精准医学杂志》
2023年第6期550-552,555,共4页
Journal of Precision Medicine
基金
2021年河南省科技厅科技攻关项目(21210231-0784)。
关键词
肺腺癌
超声检查
微血管密度
血管内皮生长因子类
缺氧诱导因子1
Α亚基
血流分级
Adenocarcinoma of lung
Ultrasonography
Microvascular density
Vascular endothelial growth factors
Hypoxia-inducible factor 1,alpha subunit
Blood flow gradation
