摘要
目的研究3+1整体康复对大疱性类天疱疮合并血管性痴呆患者认知功能的影响。方法纳入2018年1月至2022年1月收治的150例大疱性类天疱疮合并血管性痴呆患者作为研究对象,其中75例给予常规治疗和护理设为对照组;75例在常规治疗和护理基础上给予3+1整体康复设为观察组;观察2组干预前后认知功能、脑血流动力学[阻力指数(RI)、屏气指数(BHI)、舒张期峰值速度(Vmin)、收缩期峰值速度(Vmax)]及不良事件发生率。结果入院时2组认知功能评分、脑动力学指标差异无统计学意义(P>0.05),出院前1 d、出院3个月后和出院6个月后观察组认知功能评分均高于对照组(P<0.05),出院前1 d观察组RI、BHI、Vmin和Vmax均高于对照组(P<0.05),观察组不良事件总发生率低于对照组(P<0.05)。结论3+1整体康复可有效的促进大疱性类天疱疮合并血管性痴呆患者认知功能和脑动力学的改善,同时还可预防不良事件的发生,提升临床干预有效性和安全性。
Objective To study the effect of 3+1 holistic rehabilitation on cognitive function of patients with bullous pemphigoid complicated with vascular dementia.Methods A total of 150 patients with bullous pemphigoid complicated with vascular dementia who were admitted to the Outpatient and InpatientDepartment of our hospital from January 2018 to January 2022 were recruited.They were randomly divided into control group and observation group,with 75 patients per group.All patients were managed by conventional treatment and nursing,and those in the observation group were additionally intervened by 3+1 holistic rehabilitation.Cognitive function,cerebral hemodynamics,including resistance index(RI),breath-holding index(BHI),peak diastolic velocity(Vmin)and peak systolic velocity(Vmax),and incidence of adverse events were compared.Results There were no significant differences in cognitive function score and brain dynamics indexes between the two groups on admission(P>0.05).The cognitive function score 1 day before discharge,and 3 and 6 months after discharge was significantly higher in the observation group than that of the control group(P<0.05).RI,BHI,Vmin and Vmax 1 day before discharge were significantly higher in the observation group than those of the control group(P<0.05).The total incidence in the observation group was significantly lower than that of control group(P<0.05).Conclusion The 3+1 holistic rehabilitation can effectively improve the cognitive function and brain dynamics in patients with bullous pemphigoid complicated with vascular dementia,which prevents the occurrence of adverse events.It enhances the effectiveness and safety of clinical intervention.
作者
刘朋
刘桂丽
秦兰英
赵园莹
李丙南
LIU Peng;LIU Guili;QIN Lanying(Department of Dermatology,Cangzhou People’s Hospital,Hebei,Cangzhou,China)
出处
《河北医药》
CAS
2023年第23期3667-3670,共4页
Hebei Medical Journal
基金
河北省医学科学研究重点课题计划(编号:20211626)。
