摘要
骨质疏松症(osteoporosis,OP)中的表观遗传修饰是遗传和环境因素影响骨质疏松症和骨折风险增加之间的关联机制的体现。microRNA(miRNA)、长非编码RNA(lncRNA)和环状RNA(circRNA)已被证明是表观遗传调节剂,并且参与基因表达的控制,影响多种生物过程,包括骨代谢、骨形成等,是预防和治疗骨质疏松的重要靶标。因此,本文综述了关于miRNA、circRNA和lncRNA介导成骨细胞的骨质疏松症机制的研究,旨在为成骨细胞功能异常所造成的骨质疏松症提供新的研究靶点和诊疗思路。
Epigenetic modification in osteoporosis(OP)is a mechanism for genetic and environmental factors to influence the association between osteoporosis and increased fracture risk.microRNA(miRNA),long non-coding RNA(lncRNA)and circRNA(circRNA)have been shown to be epigenetic regulators,and participate in the control of gene expression,affecting a variety of biological processes,including bone metabolism and bone formation,and are important targets for the prevention and treatment of osteoporosis.Therefore,this paper reviews studies on the mechanism of osteoporosis mediated by miRNA,circRNA and lncRNA in osteoblasts,aiming to provide new research targets and diagnosis and treatment ideas for osteoporosis caused by abnormal function of osteoblasts.
作者
赵瑞
潘静
齐雅茜
雷新宇
白金霞
杨钰婷
张浩令
宋志靖
ZHAO Rui;PAN Jing;QI Yaqian;LEI Xinyu;BAI Jinxia;YANG Yuting;ZHANG Haoling;SONG Zhijing(Clinical College of Traditional Chinese Medicine,Gansu University of Traditional Chinese Medicine,Lanzhou 730000,China;School of acupuncture and moxibustion and Massage,Gansu University of Traditional Chinese Medicine,Lanzhou 730000,China;Institute of Advanced Medicine and Dentistry,Malaysian University of Science,Penang,Malaysia,13200;Dunhuang Key Laboratory of Medicine and Transformation,Ministry of Education,Lanzhou 730000,China)
出处
《中国骨质疏松杂志》
CAS
CSCD
北大核心
2023年第11期1651-1655,1693,共6页
Chinese Journal of Osteoporosis
基金
国家自然科学基金(81960877)
甘肃省高等学校创新基金(2021A-076)
甘肃省科技计划(创新基地和人才计划)项目(21JR7RA561)。
