摘要
目前对股骨头坏死微观机制的实验研究主要包括细胞层面的自噬、凋亡、坏死等,细胞包括成骨细胞、破骨细胞、骨髓间充质干细胞等,分子层面的编码与非编码RNA,基因多态性等。而表观遗传与上述病理生理发生机制有一种密切关系,其通过DNA甲基化、组蛋白修饰,到最近的RNA甲基化途径参与疾病的发生、发展。通过整理,总结中医药从实验方面治疗ONFH的表观遗传方面的相关研究,发现中药有效成分、中成药等均能在核苷酸及蛋白质水平上影响ONFH进展,发挥促进成骨或抑制成脂分化、下调炎症因子,减少骨坏死的病因,即激素与酒精对细胞的损伤。目前相关的研究还存在基础的横向与纵向研究不够深入,并且进入到临床观察的研究更少,因此希望通过本研究的系统化总结,拓展中医药在股骨头坏死领域的临床与实验应用和发展。
At present,the experimental studies on the microscopic mechanisms of osteonecrosis of the femoral head(ONFH)mainly include autophagy,apoptosis and necrosis at the cellular level,cells including osteoblasts,osteoclasts,bone marrow mesenchymal stem cells,etc.,coding and non-coding RNA at the molecular level,gene polymorphisms,etc.While epigenetics is related to the above pathophysiological mechanisms through DNA methylation,gene polymorphisms,and more.At the molecular level,coding and non-coding RNA,gene polymorphisms,etc.,while epigenetics has a close relationship with the above pathophysiological mechanisms of occurrence through DNA methylation,histone modifications and,more recently,RNA methylation pathways involved in the onset and development of ONFH.By collating and summarizing the relevant studies on the epigenetic aspects of Chinese medicine from the experimental aspect of treating ONFH,it has been found that the active ingredients of Chinese medicine and Chinese patent medicines can affect the progression of ONFH at the nucleotide and protein levels,playing a role in promoting osteogenesis or inhibiting lipogenic differentiation,down-regulating inflammatory factors and reducing the etiology of osteonecrosis,i.e.hormonal and alcohol damage to cells.There is still a lack of horizontal and vertical basic research,and even less research on clinical observation,so it is hoped that the systematic summary of this study will expand the clinical and experimental application and development of Chinese medicine in the field of osteonecrosis of the femoral head.
作者
高宇鹤
徐西林
李志刚
赫龙
薛玉满
张晓峰
GAO Yuhe;XU Xilin;LI Zhigang;HE Long;XUE Yuman;ZHANG Xiaofeng(Heilongjiang University of Traditional Chinese Medicine,Harbin,Heilongjiang 150040,China;The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin,Heilongjiang 150001,China)
出处
《中国骨质疏松杂志》
CAS
CSCD
北大核心
2023年第11期1687-1693,共7页
Chinese Journal of Osteoporosis
基金
全国名老中医药专家传承工作室建设项目(国中医药人教函【2022】75号)。
关键词
表观遗传学
中医药
股骨头坏死
研究进展
epigenetics
traditional Chinese medicine
osteonecrosis of femoral head
research progress
