摘要
目的探讨四联疗法联合盐酸小檗碱治疗幽门螺杆菌(Hp)感染的临床效果。方法选取2021年8月至2022年8月赣南医学院附属兴国医院收治的68例Hp感染患者作为研究对象,采用随机数字表法将其分为对照组和观察组各34例,对照组患者采用四联疗法(雷贝拉唑+阿莫西林+甲硝唑+枸橼酸铋甲胶囊)治疗,观察组患者采用四联疗法联合盐酸小檗碱治疗,比较两组患者的临床症状改善时间、肠道菌群(肠杆菌、乳酸杆菌、肠球菌、双歧杆菌)、炎症因子指标[肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)、白介素-6(IL-6)]、不良反应发生情况、Hp根除率及3个月复发率。结果观察组患者腹胀腹痛、暖气、反酸消失时间短于对照组,差异有统计学意义(P<0.05)。两组患者治疗后乳酸杆菌、双歧杆菌均高于本组治疗前,肠杆菌、肠球菌及血清TNF-α、hs-CRP、IL-6水平均低于本组治疗前,差异有统计学意义(P<0.05),且观察组患者乳酸杆菌、双歧杆菌均高于对照组,肠杆菌、肠球菌及血清TNF-α、hs-CRP、IL-6水平均低于对照组,差异有统计学意义(P<0.05)。观察组患者不良反应总发生率低于对照组(5.88%vs.23.53%),差异有统计学意义(P<0.05)。治疗后观察组患者Hp根除率高于对照组(94.12%vs.76.47%),差异有统计学意义(P<0.05)。对患者进行3个月的随访,随访期间均无失访,观察组患者未出现复发;对照组患者出现4例复发,复发率为11.76%,观察组3个月复发率低于对照组,差异有统计学意义(P<0.05)。结论四联疗法加用盐酸小檗碱治疗Hp感染的疗效显著,可减轻临床症状,调节肠道菌群,降低炎症因子,提高Hp根除率,减少不良反应和复发率。
Objective To investigate the clinical efficacy of quadruple therapy combined with berberine hydrochloride in the treatment of helicobacter pylori(Hp)infection.Methods A total of 68 patients with Hp infection admitted to Xingguo Hospital Affiliated to Gannan Medical University from August 2021 to August 2022 were selected as the study objects.They were divided into control group and observation group by random number table method,with 34 patients in each group.Patients in control group were treated with quadruple therapy(Rabeprazole+Amoxicillin+Metronidazole+Bismuth Citrate Capsules),observation group were treated with quadruple therapy combined with berberine hydrochloride.The improvement time of clinical symptoms,intestinal flora(enterobacter,lactobacillus,enterococcus,bifidobacterium),inflammatory factors[tumor necrosis factor-α(TNF-α),hypersensitive C-reactive protein(hs-CRP),interleukin-6(IL-6)],occurrence of adverse reactions,Hp eradication rate and 3-month recurrence rate of the two groups were compared.Results The disappearance time of abdominal distension,abdominal pain,heating and acid reflux in the observation group were shorter than that in the control group,the difference was statistically significant(P<0.05).After treatment,the levels of enterobacter,lactobacillus and bifidobacterium in two groups were higher than those before treatment,while the levels of enterococcus,enterobacter and serum TNF-α,hs-CRP and IL-6 were lower than those before treatment,the differences were statistical significant(P<0.05).The levels of lactobacillus and bifidobacterium in observation group were higher than those in control group, and the levels of enterobacter, and serum TNF-α, hs-CRP and IL-6 were lower than those of control group, and the differences were statistically significant (P<0.05). The total incidence of adverse reactions in observation group was lower than that of control group (5.88% vs. 23.53%), and the difference was statistically significant (P<0.05). After treatment, the eradication rate of Hp in observation group was higher than that in control group (94.12% vs. 76.47%), and the difference was statistically significant (P<0.05). The patients were followed up for 3 months, and no patients were lost to follow-up during the follow-up period, and no patients in the observation group had relapse. There were 4 cases of recurrence in the control group, and the recurrence rate was 11.76%. The recurrence rate at 3 months in the observation group was lower than that in the control group, the difference was statistically significant (P<0.05). Conclusion Quadruple therapy combined with Berberine Hydrochloride is effective in the treatment of Hp infection, which can reduce clinical symptoms, regulate intestinal flora, reduce inflammatory factors, improve the eradication rate of Hp, and reduce the rate of adverse reactions and recurrence.
作者
朱圣伟
钟琴
陈义华
ZHU Shengwei;ZHONG Qin;CHEN Yihua(Department of Gastroenterology,Xingguo Hospital Affiliated to Gannan Medical College,Jiangxi Province,Ganzhou 342400,China)
出处
《中国当代医药》
CAS
2023年第34期41-45,共5页
China Modern Medicine
基金
江西省赣州市指导性科技计划项目(GZ2021ZSF 654)。
关键词
幽门螺杆菌
四联疗法
盐酸小檗碱
疗效
Helicobacter pylori
Quadruple therapy
Berberine Hydrochloride
Curative effect
