摘要
目的探讨当归补血汤对早期肺癌切除术后患者的影响。方法通过随机数字表法,将2021年2月至2022年9月浙江省湖州市中医院收治的94例早期肺癌患者分成试验组和对照组,每组47例。患者均进行肺部分切除术治疗,对照组术后给予培美曲塞联合顺铂方案化疗,试验组加用当归补血汤。比较两组临床疗效、中医症候积分、肿瘤标志物水平、治疗安全性。结果试验组临床疗效优于对照组,差异有统计学意义(P<0.05)。治疗后,两组咳嗽咯血、胸闷气憋、神疲乏力、舌质紫暗评分低于治疗前,且试验组低于对照组,差异有统计学意义(P<0.05)。治疗后,两组磷脂酰激醇3-激酶、蛋白激酶、可溶性肿瘤坏死因子受体水平低于治疗前,且试验组低于对照组,差异有统计学意义(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论当归补血汤对早期肺癌切除术后患者治疗效果良好,可改善患者症状,降低肿瘤标志物水平。
Objective To investigate the effect of Danggui Buxue Decoction on patients with early lung cancer after resection.Methods By random number table method,a total of 94 patients with early lung cancer admitted to Huzhou Hospital of Traditional Chinese Medicine in Zhejiang Province from February 2021 to September 2022 were divided into experimental group and control group,with 47 cases in each group.All patients underwent partial pulmonary resection.The control group was given Pemetrexed combined with Cisplatin,and the experimental group was given angelica blood-supplementing decoction.The clinical efficacy,traditional Chinese medicine syndrome score,tumor marker level,and treatment safety of the two groups were compared.Results The clinical effect of the experimental group was better than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the scores of coughing hemoptysis,chest depression,fatigue,and tongue purpleness in the two groups were lower than before treatment,while those of the experimental group were lower than those of the control group,the differences were statistically significant(P<0.05).After treatment,the levels of phosphatidylkinol 3-kinase,protein kinase,soluble tumor necrosis factor receptor in the two groups were lower than before treatment,while those of the experimental group were lower than those of the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions(P>0.05).Conclusion Angelica Buxue Decoction has good therapeutic effect on patients with early lung cancer after resection,can improve the symptoms of patients and reduce the level of tumor markers.
作者
施胜钰
王旭文
赵良伟
杜燕青
江明
刘重斌
SHI Shengyu;WANG Xuwen;ZHAO Liangwei;DU Yanqing;JIANG Ming;LIU Chongbin(Department of General Surgery,Huzhou Traditional Chinese Medicine Hospital Affiliated to Zhejiang Chinese Medical University,Zhejiang Province,Huzhou313000,China;Department of Urology,Huzhou Traditional Chinese Medicine Hospital Affiliated to Zhejiang Chinese Medical University,Zhejiang Province,Huzhou313000,China;Department of Anesthesiology,Huzhou Traditional Chinese Medicine Hospital Affiliated to Zhejiang Chinese Medical University,Zhejiang Province,Huzhou313000,China;Medical College,Huzhou Teachers College,Zhejiang Province,Huzhou313000,China)
出处
《中国医药导报》
CAS
2023年第29期112-115,共4页
China Medical Herald
基金
浙江省中医药科学研究基金资助项目(2020ZB244)
浙江省湖州市科学技术项目(2021GY02)。
关键词
早期肺癌
肺部分切除术
当归补血汤
肿瘤标志物
Early lung cancer
Partial pneumonectomy
Angelica Buxue Decoction
Tumor markers
